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Dimethyl methylphosphonate (756-79-6)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0020494


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Some Evidence, Male, Rats
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  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Inadequate Study, Male, Mice
View
  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Dimethyl methylphosphonate (756-79-6).
Mammalian Cell Mutagenicity
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  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Dimethyl methylphosphonate (756-79-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Dimethyl methylphosphonate (756-79-6).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Dimethyl methylphosphonate (756-79-6).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Dimethyl methylphosphonate (756-79-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-323 Toxicology and Carcinogenesis Studies of Dimethyl Methylphosphonate (CASRN 756-79-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Dunnick JK, Eustis SL, Haseman JK. Development of kidney tumors in the male F344/N rat after treatment with dimethyl methylphosphonate. Fundam Appl Toxicol. 1988 Jul;11(1):91-9. doi: 10.1016/0272-0590(88)90273-4. PMID: 3209020
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of Dimethyl Methylphosphonate (756-79-6) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Dimethyl Methylphosphonate (756-79-6) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Dimethyl Methylphosphonate (756-79-6) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Dimethyl Methylphosphonate (756-79-6) in Female B6C3F1 Mice Exposed via Gavage