U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Hexachlorocyclopentadiene (77-47-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2020688

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Hexachlorocyclopentadiene (77-47-4).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Hexachlorocyclopentadiene (77-47-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Hexachlorocyclopentadiene (77-47-4).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Hexachlorocyclopentadiene (77-47-4).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information

NTP. Hexachlorocyclopentadiene (77-47-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-437 Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats and B6C3F1 Mice (inhalation studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity (C55607B) of Hexachlorocyclopentadiene (77-47-4) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55607B) of Hexachlorocyclopentadiene (77-47-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Hexachlorocyclopentadiene (77-47-4) in Micronucleus Study A24947 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Hexachlorocyclopentadiene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 725996
Summary Data
Genetic Toxicity Evaluation of Hexachlorocyclopentadiene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A66714
Summary Data

NTP Data Collections