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Isoprene (78-79-5)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2020761

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Male, Rats
  • Some Evidence, Female, Rats

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Isoprene (78-79-5).
Rodent Cytogenetics
CA
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Isoprene (78-79-5).
Micronucleus - Mice
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Isoprene (78-79-5).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Isoprene (78-79-5).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Isoprene (78-79-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-486 Toxicology and Carcinogenesis Studies of Isoprene (CASRN 78-79-5) in F344/N Rats (Inhalation Studies)
TOX-31 Toxicity Studies of Isoprene (CASRN 78-79-5) Administered by Inhalation to F344/N Rats and B6C3F1Mice
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194

Study Data

Protocol

Toxicity and Carcinogenicity Studies

6-Month Evaluation of the Toxicity (C61825C) of Isoprene (78-79-5) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C61825) of Isoprene (78-79-5) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
6-Month Evaluation of the Toxicity (C61825C) of Isoprene (78-79-5) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C61825) of Isoprene (78-79-5) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C61825B) of Isoprene (78-79-5) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Isoprene (78-79-5) in Micronucleus Study A28566 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Isoprene (78-79-5) in Micronucleus Study A63977 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Isoprene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 453451
Summary Data

DTT Data Collections