U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

1,1,2,2-Tetrachloroethane (79-34-5)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7021318

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Equivocal, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,1,2,2-Tetrachloroethane (79-34-5).
Micronucleus - Mice
View
  • Male: Positive
    Female: Positive
View
  • Male: Equivocal
    Female: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,1,2,2-Tetrachloroethane (79-34-5).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,1,2,2-Tetrachloroethane (79-34-5).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1,1,2,2-Tetrachloroethane (79-34-5).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,1,2,2-Tetrachloroethane (79-34-5).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information

NTP. 1,1,2,2-Tetrachloroethane (79-34-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-027 Bioassay of 1,1,2,2-Tetrachloroethane for Possible Carcinogenicity (CASRN 79-34-5)
TOX-45 Renal Toxicity Studies of Selected Halogenated Ethanes Administered by Gavage to F344/N Rats
TOX-49 Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice (CASRN 79-34-5)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data

Protocol

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C03554E) of 1,1,2,2-Tetrachloroethane (79-34-5) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C03554E) of 1,1,2,2-Tetrachloroethane (79-34-5) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,2,2-Tetrachloroethane (79-34-5) in Male Osborne-Mendel Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,2,2-Tetrachloroethane (79-34-5) in Female Osborne-Mendel Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,2,2-Tetrachloroethane (79-34-5) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,2,2-Tetrachloroethane (79-34-5) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane (79-34-5) in Micronucleus Study A72450 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane (79-34-5) in Micronucleus Study B72450 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 547949
Summary Data
Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 866388
Summary Data

NTP Data Collections