Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Butyl benzyl phthalate (85-68-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3020205

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Inadequate Study, Male, Rats
View
  • Positive, Female, Rats
View
  • Equivocal Evidence, Female, Rats
  • Some Evidence, Male, Rats
View
  • Equivocal Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Butyl benzyl phthalate (85-68-7).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Butyl benzyl phthalate (85-68-7).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Butyl benzyl phthalate (85-68-7).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Butyl benzyl phthalate (85-68-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Butyl benzyl phthalate (85-68-7).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Butyl benzyl phthalate (85-68-7).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information

NTP. Butyl benzyl phthalate (85-68-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-213 Carcinogenesis Bioassay of Butyl Benzyl Phthalate (CASRN 85-68-7) in F344/N Rats and B6C3F1 Mice (Feed Study)
TR-458 Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CASRN 85-68-7) in F344 Rats (Feed Studies)
Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
Final Report on the Developmental Toxicity Evaluation of Butyl Benzyl Phthalate Administered in Feed to Swiss Albino (CD-1) Mice on Gestational Days 6 to 15
Final Report on the Developmental Toxicity Evaluation of Butyl Benzyl Phthalate Administered in Feed to Swiss Albino (CD-1) Mice on Gestational Days 6 to 15--Laboratory Supplement
Developmental Toxicity Evaluation of Butyl Benzyl Pthalate Administered in Feed to CD Rats on Gestational Days 6 to 15
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data

Protocol

Toxicity and Carcinogenicity Studies

26-Week Evaluation of the Toxicity (C54375B) of Butyl Benzyl Phthalate (85-68-7) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Butyl Benzyl Phthalate (85-68-7) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Butyl Benzyl Phthalate (85-68-7) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Butyl Benzyl Phthalate (85-68-7) in Male B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Butyl Benzyl Phthalate (85-68-7) in Female B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C54375C) of Butyl Benzyl Phthalate (85-68-7) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C54375C) of Butyl Benzyl Phthalate (85-68-7) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Butyl Benzyl Phthalate (85-68-7) in Micronucleus Study A61034 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Butyl Benzyl Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 834175
Summary Data
Genetic Toxicity Evaluation of Butyl Benzyl Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 933175
Summary Data

Other NTP Studies

ADME/TK Evaluation (S0049) of Butyl benzyl phthalate (85-68-7) in F344 Rats Exposed via Dermal Application
Data Summary
Prenatal Developmental Toxicity Study (TER88025) of Butyl Benzyl Phthalate (85-68-7) in Sprague-Dawley Rats Exposed via Dosed Feed
Individual and Summary Data
Prenatal Developmental Toxicity Study (TER89026) of Butyl Benzyl Phthalate (85-68-7) in Swiss CD-1 Mice Exposed via Dosed Feed
Individual and Summary Data

DTT Data Collections