o-Nitrotoluene (88-72-2)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4025791
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
| Micronucleus - Mice |
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| Micronucleus - Rats |
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| Mammalian Cell Cytogenetics | |
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| CA | SCE |
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| Bacterial Mutagenicity |
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Publications
TR-504
Toxicology and Carcinogenesis Studies of o-Nitrotoluene (CASRN 88-72-2) in F344/N Rats and B6C3F1 Mice (Feed Studies)
TOX-23
Toxicity Studies of o-,m-, and p- Nitrotoluenes (CASRNs 88-72-2, 99-08-1, 99-99-0) Administered in Dosed Feed to F344/N Rats and B6C3F1Mice
TOX-44
Comparative Toxicity and Carcinogenicity Studies ofo-Nitrotoluene (CASRN 88-72-2) ando-Toluidine Hydrochloride (CASRN 636-21-5) Administered in Feed to Male F344/N Rats
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
Study Data
Toxicity and Carcinogenicity Studies
26-Week Evaluation of the Toxicity (C62340C) of o-Nitrotoluene (88-72-2) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
3-Month Evaluation of the Toxicity (C62340) of o-Nitrotoluene (88-72-2) in F344 Rats Exposed via Dosed Feed. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C62340B) of NTP-88 Diet Study (o-Nitrotoluene) (88-72-2) in F344 Rats Exposed via Dosed Feed. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C62340) of o-Nitrotoluene (88-72-2) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C62340B) of NTP-88 Diet Study (o-Nitrotoluene) (88-72-2) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C62340) of o-Nitrotoluene (88-72-2) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C62340B) of NTP-88 Diet Study (o-Nitrotoluene) (88-72-2) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C62340) of o-Nitrotoluene (88-72-2) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C62340B) of NTP-88 Diet Study (o-Nitrotoluene) (88-72-2) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C62340D) of o-Nitrotoluene (88-72-2) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C62340D) of o-Nitrotoluene (88-72-2) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of o-Nitrotoluene (88-72-2) in Micronucleus Study A25222 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of o-Nitrotoluene (88-72-2) in Micronucleus Study A29734 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of o-Nitrotoluene (88-72-2) in Micronucleus Study A80173 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of o-Nitrotoluene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 192331
Summary Data
- G06 - Ames Summary Data (142 KB)
Genetic Toxicity Evaluation of o-Nitrotoluene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 692737
Summary Data
- G06 - Ames Summary Data (141 KB)
Other NTP Studies
2-Week Immunotoxicity Evaluation (IMM95002) of m-Nitrotoluene (99-08-1) in Female B6C3F1 Mice Exposed via Gavage
B6CF1 Mice Individual and Summary Data
- Absolute Leukocyte Differentials (10 kB)
- Host Resistance to B16F10 Melanoma Tumors (4 kB)
- Infection With Plasmodium Yoelii (5 kB)
- Mixed Leukocyte Response (16 kB)
- Natural Killer Activity (10 kB)
- Organ Weights (43 kB)
- PYB6 Tumor Incidence (17 kB)
- Resistance to Infection with Listeria Monocytogenes (27 kB)
- Resistance to Infection with Streptococcus Pneumoniae (28 kB)
- Reticulocytes (7 kB)
- Serum Complement (CH50) (units/ml) (8 kB)
- T-Dependent AB Response Day 4 (10 kB)
- T-Dependent AB Response Day 5 (10 kB)