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4-Nitro-o-phenylenediamine (99-56-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID9020958

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 4-Nitro-o-phenylenediamine (99-56-9).
Rodent Cytogenetics
CA SCE
  • View
    • Negative (Nonstandard Protocol)
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 4-Nitro-o-phenylenediamine (99-56-9).
Micronucleus - Mice
View
  • Male: Equivocal
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 4-Nitro-o-phenylenediamine (99-56-9).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 4-Nitro-o-phenylenediamine (99-56-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 4-Nitro-o-phenylenediamine (99-56-9).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive
View
  • Positive

Citation Information

NTP. 4-Nitro-o-phenylenediamine (99-56-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-180 Bioassay of 4-Nitro-o-phenylenediamine for Possible Carcinogenicity (CASRN 99-56-9)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Nitro-o-phenylenediamine (99-56-9) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Nitro-o-phenylenediamine (99-56-9) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Nitro-o-phenylenediamine (99-56-9) in Male B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Nitro-o-phenylenediamine (99-56-9) in Female B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 4-Nitro-o-phenylenediamine (99-56-9) in Micronucleus Study A82327 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 4-Nitro-o-phenylenediamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 274391
Summary Data
Genetic Toxicity Evaluation of 4-Nitro-o-phenylenediamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 541901
Summary Data
Genetic Toxicity Evaluation of 4-Nitro-o-phenylenediamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 803155
Summary Data

DTT Data Collections