Goldenseal root (GOLDENSEALRT)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6031384
Publications
TR-562
Toxicology and Carcinogenesis Studies of Goldenseal Root Powder (HYDRASTIS CANADENSIS) in F344/N Rats and B6C3F1 Mice (Feed studies)
Final Study Report Developmental Toxicity Evaluation for Goldenseal Root Powder (Hydrastis Canadensis) Administered in the Feed to Sprague-Dawley (CD®) Rats on Gestational Days 6 to 20
FINAL STUDY REPORT DEVELOPMENTAL TOXICITY EVALUTATION FOR GOLDENSEAL ROOT POWDER (HYDRASTIS CANADENSIS) ADMINISTERED IN THE FEED TO SPRAGUE-DAWLWY (CD(r)) RATS ON GESTATIONAL DAYS 6 TO 20
Final Study Report Developmental Toxicity Evaluation for Goldenseal (Hydrastis canadensis) root powder Administered in the Feed to Swiss (CD-1®) Mice on Gestational Days 6-17
Final Study Report?Developmental Toxicity Evaluation for Goldenseal (Hydrastis canadensis) root powder Administered in the Feed to Swiss (CD-1®) Mice on Gestational Days 6-17
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C99007) of Goldenseal Root Powder (GOLDENSEALRT) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C99007) of Goldenseal Root Powder (GOLDENSEALRT) in F344 Rats Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C99007B) of Goldenseal Root Powder (GOLDENSEALRT) in F344 Rats Exposed via Dosed Feed. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
2-Week Evaluation of the Toxicity (C99007) of Goldenseal Root Powder (GOLDENSEALRT) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C99007) of Goldenseal Root Powder (GOLDENSEALRT) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C99007B) of Goldenseal Root Powder (GOLDENSEALRT) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C99007B) of Goldenseal Root Powder (GOLDENSEALRT) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C99007B) of Goldenseal Root Powder (GOLDENSEALRT) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C99007B) of Goldenseal Root Powder (GOLDENSEALRT) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C99007B) of Goldenseal Root Powder (GOLDENSEALRT) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Goldenseal Root Powder (GOLDENSEALRT) in Micronucleus Study A21831 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Goldenseal Root Powder in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A83314
Summary Data
- G06 - Ames Summary Data (67 KB)
Other NTP Studies
Prenatal Developmental Toxicity Pilot Study (TRP98007) of Goldenseal Root Powder (GOLDENSEALRT) in Sprague-Dawley Rats Exposed via Dosed Feed
Individual and Summary Data
- Dam Data: Dam Body Weights (20 kB)
- Dam Data: Dam Feed Consumption (18 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (18 kB)
- Dam Data: Organ Weights (20 kB)
- Fetal Data: All Malformations (456 kB)
- Fetal Data: All Variations (456 kB)
- Fetal Data: Fetal Body Weights (452 kB)
- Live Litter: All Litter (455 kB)
- Live Litter: Live Litter (456 kB)
Prenatal Developmental Toxicity Pilot Study (TRP99007) of Goldenseal Root Powder (GOLDENSEALRT) in Swiss CD-1 Mice Exposed via Dosed Feed
Individual and Summary Data
- Dam Data: Dam Body Weights (18 kB)
- Dam Data: Dam Feed Consumption (17 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (17 kB)
- Dam Data: Organ Weights (20 kB)
- Fetal Data: All Malformations (403 kB)
- Fetal Data: Fetal Body Weights (399 kB)
- Live Litter: All Litter (402 kB)
- Live Litter: Live Litter (403 kB)
Prenatal Developmental Toxicity Study (TER98007) of Goldenseal Root Powder (GOLDENSEALRT) in Sprague-Dawley Rats Exposed via Dosed Feed
Individual and Summary Data
- Dam Data: Dam Body Weights (26 kB)
- Dam Data: Dam Feed Consumption (24 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (24 kB)
- Dam Data: Organ Weights (26 kB)
- Fetal Data: All Malformations (694 kB)
- Fetal Data: All Variations (693 kB)
- Fetal Data: Fetal Body Weights (689 kB)
- Live Litter: All Litter (691 kB)
- Live Litter: Live Litter (694 kB)
Prenatal Developmental Toxicity Study (TER99004) of Goldenseal Root Powder (GOLDENSEALRT) in Swiss CD-1 Mice Exposed via Dosed Feed
Individual and Summary Data
- Dam Data: Dam Body Weights (20 kB)
- Dam Data: Dam Feed Consumption (18 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Dam Water Consumption (18 kB)
- Dam Data: Organ Weights (21 kB)
- Fetal Data: All Malformations (522 kB)
- Fetal Data: All Variations (522 kB)
- Fetal Data: Fetal Body Weights (518 kB)
- Live Litter: All Litter (520 kB)
- Live Litter: Live Litter (523 kB)