Perfluorinated Compounds: Sulfonates

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Perfluorinated Compounds: Sulfonates.
Micronucleus - Rats
View Male: Negative Female: Negative
View Male: Negative Female: Negative
View Male: Negative Female: Positive

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Perfluorinated Compounds: Sulfonates.
Bacterial Mutagenicity
View Equivocal
View Negative

Citation Information

NTP. Perfluorinated Compounds: Sulfonates. Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TOX-96 NTP Report on the Toxicity Studies of Perfluorinated Compounds: Sulfonates Administered via Oral Gavage in Hsd: Sprague Dawley SD Rats

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

28-Day Evaluation of the Toxicity (C06100) of Perfluorohexane sulfonate potassium salt (PFHSKslt) (3871-99-6) in Harlan Sprague-Dawley Rats Exposed via Gavage

Study Tables

E01 - Animal Removal Summary By Treatment Group (12 kB)
E02 - Animals Removed from Experiment (67 kB)
E03 - Growth Curves (368 kB)
E04 - Mean Body Weights and Survival Table (16 kB)
E05 - Clinical Observations Summary (14 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (29 kB)
P04 - Neoplasms by Individual Animal (215 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (217 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (75 kB)
P11 - Statistical Analysis of Survival Data (28 kB)
P14 - Individual Animal Pathology Data (276 kB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (216 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (30 kB)
P40 - Survival Curves (427 kB)
PA06 - Organ Weights Summary Females (71 kB)
PA06 - Organ Weights Summary Males (71 kB)
PA41 - Clinical Chemistry Summary Females (164 kB)
PA41 - Clinical Chemistry Summary Males (164 kB)
PA43 - Hematology Summary Females (149 kB)
PA43 - Hematology Summary Males (148 kB)
PA45 - Liver Special Studies Summary (36 kB)
PA48 - Summary of Tissue Concentration Males (54 kB)
PA48 - Summary of Tissue Concentration Females (42 kB)
R06 - Andrology Summary (50 kB)
R07 - Hormone Summary Females (43 kB)
R07 - Hormone Summary Males (46 kB)
Results of Vaginal Cytology Study Using Transition Matrix Approach (44 kB)
Summary of Estrous Stages and Cycle Data (54 kB)
Vaginal Cytology Plot (17 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (18 kB)
Female Individual Animal Non Neoplastic Pathology Data (20 kB)
Female Individual Animal Survival Data (11 kB)
Female Individual Animal Terminal Body Weight Data (19 kB)
Individual Animal Andrology Data (7 kB)
Individual Animal Clinical Chemistry Data Females (10 kB)
Individual Animal Clinical Chemistry Data Males (11 kB)
Individual Animal Hematology Data Females (12 kB)
Individual Animal Hematology Data Males (12 kB)
Individual Animal Hormone Data Females (8 kB)
Individual Animal Hormone Data Males (8 kB)
Individual Animal Liver Special Studies Data (6 kB)
Individual Animal Organ Weight Data Females (9 kB)
Individual Animal Organ Weight Data Males (10 kB)
Individual Animal Tissue Concentration Data Females (7 kB)
Individual Animal Tissue Concentration Data Males (7 kB)
Individual Vaginal Cytology Data (25 kB)
Individual_Animal_PCR_Data (24 kB)
Male Individual Animal Body Weight Data (18 kB)
Male Individual Animal Non Neoplastic Pathology Data (35 kB)
Male Individual Animal Survival Data (11 kB)
Male Individual Animal Terminal Body Weight Data (19 kB)
Male Individual Clinical Observations (2 kB)

Data

28-Day Evaluation of the Toxicity (C07040) of Perfluorobutane sulfonate (PFBS) (375-73-5) in Harlan Sprague-Dawley Rats Exposed via Gavage

Study Tables

E01 - Animal Removal Summary By Treatment Group (13 kB)
E02 - Animals Removed from Experiment (67 kB)
E03 - Growth Curves (379 kB)
E04 - Mean Body Weights and Survival Table (16 kB)
E05 - Clinical Observations Summary (18 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (37 kB)
P04 - Neoplasms by Individual Animal (258 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (279 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (204 kB)
P11 - Statistical Analysis of Survival Data (28 kB)
P14 - Individual Animal Pathology Data (295 kB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (259 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (36 kB)
P40 - Survival Curves (421 kB)
PA06 - Organ Weights Summary (112 kB)
PA41 - Clinical Chemistry Summary (Revised) (259 kB)
PA43 - Hematology Summary (263 kB)
PA45 - Liver Special Studies Summary (31 kB)
PA48 - Summary of Tissue Concentration (71 kB)
R06 - Andrology Summary (50 kB)
R07 - Hormone Summary (61 kB)
Results of Vaginal Cytology Study Using Transition Matrix Approach (42 kB)
Summary of Estrous Stages and Cycle Data (59 kB)
Vaginal Cytology Plot (17 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (18 kB)
Female Individual Animal Non Neoplastic Pathology Data (52 kB)
Female Individual Animal Survival Data (11 kB)
Female Individual Animal Terminal Body Weight Data (19 kB)
Female Individual Clinical Observations (5 kB)
Individual Animal Andrology Data (7 kB)
Individual Animal Clinical Chemistry Data (15 kB)
Individual Animal Hematology Data (17 kB)
Individual Animal Hormone Data (11 kB)
Individual Animal Liver Special Studies Data (6 kB)
Individual Animal Organ Weight Data (13 kB)
Individual Animal Tissue Concentration Data (10 kB)
Individual Vaginal Cytology Data (24 kB)
Individual_Animal_PCR_Data (23 kB)
Male Individual Animal Body Weight Data (18 kB)
Male Individual Animal Non Neoplastic Pathology Data (69 kB)
Male Individual Animal Survival Data (11 kB)
Male Individual Animal Terminal Body Weight Data (19 kB)
Male Individual Clinical Observations (3 kB)

Data

28-Day Evaluation of the Toxicity (C20617) of Perfluorooctane Sulfonate (PFOS) (1763-23-1) in Harlan Sprague-Dawley Rats Exposed via Gavage

Study Tables

E01 - Animal Removal Summary By Treatment Group (12 kB)
E02 - Animals Removed from Experiment (66 kB)
E03 - Growth Curves (363 kB)
E04 - Mean Body Weights and Survival Table (16 kB)
E05 - Clinical Observations Summary (14 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
P04 - Neoplasms by Individual Animal (215 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (227 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (141 kB)
P11 - Statistical Analysis of Survival Data (27 kB)
P14 - Individual Animal Pathology Data (279 kB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (217 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 kB)
P40 - Survival Curves (399 kB)
PA06 - Organ Weights Summary (118 kB)
PA41 - Clinical Chemistry Summary (307 kB)
PA43 - Hematology Summary (276 kB)
PA45 - Liver Special Studies Summary (36 kB)
PA48 - Summary of Tissue Concentration (73 kB)
R06 - Andrology Summary (50 kB)
R07 - Hormone Summary (68 kB)
Results of Vaginal Cytology Study Using Transition Matrix Approach (44 kB)
Summary of Estrous Stages and Cycle Data (54 kB)
Vaginal Cytology Plot (17 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (18 kB)
Female Individual Animal Non Neoplastic Pathology Data (43 kB)
Female Individual Animal Survival Data (11 kB)
Female Individual Animal Terminal Body Weight Data (19 kB)
Individual Animal Andrology Data (7 kB)
Individual Animal Clinical Chemistry Data (16 kB)
Individual Animal Hematology Data (18 kB)
Individual Animal Hormone Data (11 kB)
Individual Animal Liver Special Studies Data (6 kB)
Individual Animal Organ Weight Data (15 kB)
Individual Animal Tissue Concentration Data (10 kB)
Individual Vaginal Cytology Data (23 kB)
Individual_Animal_PCR_Data (25 kB)
Male Individual Animal Body Weight Data (18 kB)
Male Individual Animal Non Neoplastic Pathology Data (52 kB)
Male Individual Animal Survival Data (11 kB)
Male Individual Animal Terminal Body Weight Data (19 kB)
Male Individual Clinical Observations (4 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of Perfluorobutane Sulfonate (PFBS) (375-73-5) in Micronucleus Study G04006 in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (74 kB)
Individual Animal In Vivo Micronucleus Data (9 kB)

Data

Genetic Toxicity Evaluation of Perfluorobutane Sulfonate (PFBS) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A32037

Summary Data

G06 - Ames Summary Data (80 kB)

Data

Genetic Toxicity Evaluation of Perfluorohexane Sulfonate Potassium Salt (PFHSKslt) (3871-99-6) in Micronucleus Study G06100 in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (79 kB)
Individual Animal In Vivo Micronucleus Data (10 kB)

Data

Genetic Toxicity Evaluation of Perfluorooctane Sulfonate (1763-23-1) in Micronucleus Study G04004 in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (79 kB)
Individual Animal In Vivo Micronucleus Data (10 kB)

Data

Genetic Toxicity Evaluation of Perfluorooctane Sulfonate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A33826

Summary Data

G06 - Ames Summary Data (88 kB)

Other NTP Studies

Data

Toxicokinetic Evaluation (C06100) of Perfluorohexane-1-Sulphonic Acid Potassium Salt (DTXSID3037709) in Rat

Data

Original Data (47 kB)

Data

Toxicokinetic Evaluation (CHEM10076) of Perfluorooctane Sulfonate (DTXSID3031864) in Rat

Data

Annotated Group Parameters (71 kB)
Annotated Individual Animal Data (47 kB)
Summary Data (264 kB)

Perfluorinated Compounds: Sulfonates

Study Results

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

28-Day Evaluation of the Toxicity (C06100) of Perfluorohexane sulfonate potassium salt (PFHSKslt) (3871-99-6) in Harlan Sprague-Dawley Rats Exposed via Gavage

Study Tables

Individual Animal Data

28-Day Evaluation of the Toxicity (C07040) of Perfluorobutane sulfonate (PFBS) (375-73-5) in Harlan Sprague-Dawley Rats Exposed via Gavage

Study Tables

Individual Animal Data

28-Day Evaluation of the Toxicity (C20617) of Perfluorooctane Sulfonate (PFOS) (1763-23-1) in Harlan Sprague-Dawley Rats Exposed via Gavage

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Perfluorobutane Sulfonate (PFBS) (375-73-5) in Micronucleus Study G04006 in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Perfluorobutane Sulfonate (PFBS) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A32037

Summary Data

Genetic Toxicity Evaluation of Perfluorohexane Sulfonate Potassium Salt (PFHSKslt) (3871-99-6) in Micronucleus Study G06100 in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Perfluorooctane Sulfonate (1763-23-1) in Micronucleus Study G04004 in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Perfluorooctane Sulfonate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A33826

Summary Data

Other NTP Studies

Toxicokinetic Evaluation (C06100) of Perfluorohexane-1-Sulphonic Acid Potassium Salt (DTXSID3037709) in Rat

Data

Toxicokinetic Evaluation (CHEM10076) of Perfluorooctane Sulfonate (DTXSID3031864) in Rat

Data