U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

TR-296: Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1), Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Male, Rats
View
  • No Evidence, Male, Rats
View
  • No Evidence, Female, Rats
View
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Male, Mice
View
  • No Evidence, Male, Mice
View
  • No Evidence, Female, Mice
View
  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to TR-296: Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1), Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to TR-296: Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1), Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-296: Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1), Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information


NTP. TR-296: Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1), Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-296 Toxicology and Carcinogenesis Studies of Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN 55566-30-8) and Tetrakis(hydroxymethyl)phosphonium chloride (THPC) (CASRN 124-64-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Chloride (124-64-1) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Sulfate (55566-30-8) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Chloride (124-64-1) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Sulfate (55566-30-8) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Chloride (124-64-1) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Sulfate (55566-30-8) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Chloride (124-64-1) in Female B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Sulfate (55566-30-8) in Female B6C3F1 Mice Exposed via Gavage