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TR-357: Hydrochlorothiazide (58-93-5)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Male, Rats
View
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Equivocal Evidence, Male, Mice
View
  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to TR-357: Hydrochlorothiazide (58-93-5).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to TR-357: Hydrochlorothiazide (58-93-5).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to TR-357: Hydrochlorothiazide (58-93-5).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-357: Hydrochlorothiazide (58-93-5).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. TR-357: Hydrochlorothiazide (58-93-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-357 Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Hydrochlorothiazide (58-93-5) in Male F344 Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Hydrochlorothiazide (58-93-5) in Female F344 Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Hydrochlorothiazide (58-93-5) in Male B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Hydrochlorothiazide (58-93-5) in Female B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Hydrochlorothiazide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 715548
Summary Data