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TR-439: Methylphenidate hydrochloride (298-59-9)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Some Evidence, Female, Mice
  • Some Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to TR-439: Methylphenidate hydrochloride (298-59-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-439: Methylphenidate hydrochloride (298-59-9).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information

NTP. TR-439: Methylphenidate hydrochloride (298-59-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-439 Toxicology and Carcinogenesis Studies of Methylphenidate Hydrochloride (CASRN 298-59-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity (C56280B) of Methylphenidate Hydrochloride (298-59-9) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C56280B) of Methylphenidate Hydrochloride (298-59-9) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Methylphenidate Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 214507
Summary Data
Genetic Toxicity Evaluation of Methylphenidate Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 501412
Summary Data