TR-579: N,N-Dimethyl-p-toluidine (99-97-8)
Study Results
Chronic Bioassay Level of Evidence
| Rats | |
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| In Vivo Alkaline Comet Assay - Rats |
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| In Vivo Alkaline Comet Assay - Mice |
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| Bacterial Mutagenicity |
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Publications
TR-579
Toxicology and Carinogenesis Studies of N,N-Dimethyl-p-Toluidine (CASRN 99-97-8) in F344/N Rats and B6C3F1/N Mice (Gavage Studies)
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Toxicity (C20107) of N,N-Dimethyl-p-toluidine (99-97-8) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C20107) of N,N-Dimethyl-p-toluidine (99-97-8) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C20107) of N,N-Dimethyl-p-toluidine (99-97-8) in F344/N Rats Exposed via Gavage
Study Tables
- E03 - Growth Curves (68 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (58 kB)
- P04 - Neoplasms by Individual Animal (643 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (46 kB)
- P08 - Statistical Analysis of Primary Tumors (281 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (871 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (567 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (594 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (60 kB)
- P40 - Survival Curves (64 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (346 kB)
- Female Individual Animal Clinical Observations (314 kB)
- Female Individual Animal Neoplastic Pathology Data (147 kB)
- Female Individual Animal Non Neoplastic Pathology Data (1 mB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (376 kB)
- Male Individual Animal Clinical Observations (136 kB)
- Male Individual Animal Neoplastic Pathology Data (174 kB)
- Male Individual Animal Non Neoplastic Pathology Data (2 mB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (33 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20107) of N,N-Dimethyl-p-toluidine (99-97-8) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E03 - Growth Curves (66 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (58 kB)
- P04 - Neoplasms by Individual Animal (676 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (48 kB)
- P08 - Statistical Analysis of Primary Tumors (212 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (841 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (500 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (596 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (60 kB)
- P40 - Survival Curves (64 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (318 kB)
- Female Individual Animal Clinical Observations (44 kB)
- Female Individual Animal Neoplastic Pathology Data (174 kB)
- Female Individual Animal Non Neoplastic Pathology Data (821 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (354 kB)
- Male Individual Animal Clinical Observations (96 kB)
- Male Individual Animal Neoplastic Pathology Data (173 kB)
- Male Individual Animal Non Neoplastic Pathology Data (839 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (34 kB)
Special Evaluation of the Toxicity (C20107) of N,N-Dimethyl-p-toluidine (99-97-8) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
Individual Animal Data
Genetic Toxicology Studies
Genetic Toxicity Evaluation of N,N-Dimethyl-p-toluidine (99-97-8) in DNA Damage Study G00059 in Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of N,N-Dimethyl-p-toluidine (99-97-8) in DNA Damage Study G1104ZA in B6C3F1 Mice
Genetic Toxicity Evaluation of N,N-Dimethyl-p-toluidine (99-97-8) in Micronucleus Study A29310 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of N,N-Dimethyl-p-toluidine (99-97-8) in Micronucleus Study G1104Z in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of N,N-Dimethyl-p-toluidine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A14805
Summary Data
- G06 - Ames Summary Data (170 KB)
Genetic Toxicity Evaluation of N,N-Dimethyl-p-toluidine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A41919
Summary Data
- G06 - Ames Summary Data (82 KB)