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1,4-Dichlorobenzene (106-46-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1020431


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Male, Rats
View
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Male, Mice
View
  • Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 1,4-Dichlorobenzene (106-46-7).
Rodent Cytogenetics
CA
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,4-Dichlorobenzene (106-46-7).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,4-Dichlorobenzene (106-46-7).
Mammalian Cell Mutagenicity
View
  • Equivocal
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,4-Dichlorobenzene (106-46-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,4-Dichlorobenzene (106-46-7).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. 1,4-Dichlorobenzene (106-46-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-319 Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dichlorobenzene (p-Dichlorobenzene) (106-46-7) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dichlorobenzene (p-Dichlorobenzene) (106-46-7) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dichlorobenzene (p-Dichlorobenzene) (106-46-7) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dichlorobenzene (p-Dichlorobenzene) (106-46-7) in Female B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 1,4-Dichlorobenzene (p-Dichlorobenzene) (106-46-7) in Micronucleus Study 447196 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,4-Dichlorobenzene (p-Dichlorobenzene) (106-46-7) in Micronucleus Study A90787 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,4-Dichlorobenzene (p-Dichlorobenzene) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 590003
Summary Data