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3,3',4,4'-Tetrachloroazobenzene (14047-09-7)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 3,3',4,4'-Tetrachloroazobenzene (14047-09-7).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Positive
    Female: Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 3,3',4,4'-Tetrachloroazobenzene (14047-09-7).
Bacterial Mutagenicity
View
  • Positive
View
  • Negative
View
  • Negative

Citation Information


NTP. 3,3',4,4'-Tetrachloroazobenzene (14047-09-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-558 Toxicology and Carcinogenesis Studies of 3,3',4,4'-Tetrachloroazobenzene (CASRN 14047-09-7) in Harlan Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies)
TOX-65 Toxicity Studies of 3,3',4,4'-Tetrachloroazobenzene Administered by Gavage to F344/N Rats and B6C3F1Mice (CASRN 14047-09-7)
Witt, K.L., Zeiger, E., Tice, R.R., and van Birgelen, A.P.J.M. The genetic toxicity of 3,3',4,4'-tetrachloroazobenzene and 3,3',4,4'-tetrachloroazoxybenzene: discordance between acute mouse bone marrow and subchronic mouse peripheral blood micronucleus test results. Mutation Res. Vol. 472 (2000) 147-154
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Study Data


Toxicity and Carcinogenicity Studies


2-Week Evaluation of the Toxicity (C88148) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C88148) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in F344 Rats Exposed via Gavage. NTP Special Study
2-Week Evaluation of the Toxicity (C88148) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C88148) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C88148) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C88148B) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in Harlan Sprague-Dawley Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C88148B) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in Sprague-Dawley Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C88148) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C88148C) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in Harlan Sprague-Dawley Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C88148C) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in Micronucleus Study A43252 in B6C3F1 Mice
Genetic Toxicity Evaluation of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in Micronucleus Study A95885 in B6C3F1 Mice
Genetic Toxicity Evaluation of 3,3',4,4'-Tetrachloroazobenzene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A17768
Summary Data
Genetic Toxicity Evaluation of 3,3',4,4'-Tetrachloroazobenzene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A30420
Summary Data
Genetic Toxicity Evaluation of 3,3',4,4'-Tetrachloroazobenzene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A71232
Summary Data

Other NTP Studies


Toxicokinetic Evaluation (S0665) of 3,3',4,4'-Tetrachloroazobenzene (14047-09-7) in Sprague-Dawley Rats Exposed via Gavage
Data