Perfluorodecanoic acid (335-76-2)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3031860
Publications
TOX-97
NTP Report on the Toxicity Studies of Perfluorinated Compounds: Carboxylates Administered via Oral Gavage in Hsd: Sprague Dawley SD Rats
Immunotoxic and Hepatotoxic Effects of Perfluoro-n-decanoic Acid (PFDA) on Female Harlan Sprague–Dawley Rats and B6C3F1/N Mice when Administered by Oral Gavage for 28 Days
Rachel P. Frawley, Matthew Smith, Mark F. Cesta, Schantel Hayes-Bouknight, Chad Blystone, Grace E. Kissling, Shawn Harris & Dori Germolec.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1080/1547691X.2018.1445145 PMID: 29514525
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1080/1547691X.2018.1445145 PMID: 29514525
A high-throughput toxicity screen of 42 per- and polyfluoroalkyl substances (PFAS) and functional assessment of migration and gene expression in human placental trophoblast cells
Bevin E. Blake, Brittany P. Rickard, and Suzanne E. Fenton
DOI: https://doi.org/10.22427/NTP-DATA-025-00001-0001-000-9
DOI: https://doi.org/10.22427/NTP-DATA-025-00001-0001-000-9
Toxicokinetics of Perfluorohexanoic acid (PFHxA), Perfluorooctanoic acid (PFOA), and Perfluorodecanoic Acid (PFDA) in Male and Female Hsd:Sprague Dawley SD Rats following Intravenous or Gavage Administration
Dzierlenga A.L, Robinson V.G, Waidyanatha S, DeVito M.J, Eifrid M.A, Gibbs S.T, Granville C.A, *Blystone C.R
DOI: https://doi.org/10.22427/NTP-DATA-002-00037-0002-000-4
DOI: https://doi.org/10.22427/NTP-DATA-002-00037-0002-000-4
Unraveling Human Hepatocellular Responses to PFAS and Aqueous Film-Forming Foams (AFFFs) for Molecular Hazard Prioritization and In Vivo Translation
Kevin A. Mauge-Lewis1,‡, Sreenivasa C. Ramaiahgari1,‡, Scott S. Auerbach1, Georgia K. Roberts1, Suramya Waidyanatha1, Suzanne E Fenton1, Dhiral P. Phadke2, Michele R. Balik-Meisner2, Arpit Tandon2, Deepak Mav2, Brian Howard2, Ruchir Shah2, Barney Sparrow3, Jenni Gorospe3, Stephen S. Ferguson1
‡These authors equally contributed to this study.
1Division of Translational Toxicology at the National Institute for Environmental Sciences, Research Triangle Park, North Carolina
2Sciome, Research Triangle Park, North Carolina
3Battelle, Columbus, Ohio
Environmental Science and Technology, (2025) DOI: https://doi.org/10.1021/acs.est.4c10595 PMID: 398893674 PMCID: PMC11823446
DOI: https://doi.org/10.22427/NTP-DATA-500-017-001-000-4
‡These authors equally contributed to this study.
1Division of Translational Toxicology at the National Institute for Environmental Sciences, Research Triangle Park, North Carolina
2Sciome, Research Triangle Park, North Carolina
3Battelle, Columbus, Ohio
Environmental Science and Technology, (2025) DOI: https://doi.org/10.1021/acs.est.4c10595 PMID: 398893674 PMCID: PMC11823446
DOI: https://doi.org/10.22427/NTP-DATA-500-017-001-000-4
Study Data
Toxicity and Carcinogenicity Studies
28-Day Evaluation of the Toxicity (C20615) of Perfluorodecanoic Acid (PFDA) (335-76-2) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (67 kB)
- E03 - Growth Curves (371 kB)
- E04 - Mean Body Weights and Survival Table (16 kB)
- E05 - Clinical Observations Summary (14 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
- P04 - Neoplasms by Individual Animal (225 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (35 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (238 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (154 kB)
- P11 - Statistical Analysis of Survival Data (27 kB)
- P14 - Individual Animal Pathology Data (282 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (224 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 kB)
- P40 - Survival Curves (417 kB)
- PA06 - Organ Weights Summary (118 kB)
- PA41 - Clinical Chemistry Summary (307 kB)
- PA43 - Hematology Summary (276 kB)
- PA45 - Liver Special Studies Summary (36 kB)
- PA48 - Summary of Tissue Concentration (73 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary (68 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (42 kB)
- Summary of Estrous Stages and Cycle Data (59 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (18 kB)
- Female Individual Animal Non Neoplastic Pathology Data (46 kB)
- Female Individual Animal Survival Data (11 kB)
- Female Individual Animal Terminal Body Weight Data (19 kB)
- Female Individual Clinical Observations (2 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data (16 kB)
- Individual Animal Hematology Data (18 kB)
- Individual Animal Hormone Data (12 kB)
- Individual Animal Liver Special Studies Data (6 kB)
- Individual Animal Organ Weight Data (15 kB)
- Individual Animal Tissue Concentration Data (10 kB)
- Individual Vaginal Cytology Data (23 kB)
- Individual_Animal_PCR_Data (24 kB)
- Male Individual Animal Body Weight Data (18 kB)
- Male Individual Animal Non Neoplastic Pathology Data (74 kB)
- Male Individual Animal Survival Data (11 kB)
- Male Individual Animal Terminal Body Weight Data (19 kB)
- Male Individual Clinical Observations (4 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Perfluorodecanoic Acid (335-76-2) in Micronucleus Study G92006 in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Perfluorodecanoic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A10025
Summary Data
- G06 - Ames Summary Data (81 KB)
Other NTP Studies
Toxicokinetic Evaluation (C20615) of Perfluorodecanoic Acid (335-76-2) in Harlan Sprague-Dawley Rats Exposed via Intravenous Injection and Gavage
Toxicokinetic Evaluation (K10214) of Perfluorodecanoic Acid (DTXSID3031860) in Rat
Data
- Annotated Group Parameters (19 kB)
- Annotated Individual Animal Data (122 kB)
- Original Data (41 kB)
- Summary Data (238 kB)