Perfluorinated Compounds: Carboxylates
Study Results
Genetic Toxicology
| Micronucleus - Rats |
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| In Vivo Alkaline Comet Assay - Rats |
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| Bacterial Mutagenicity |
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Publications
TOX-97
NTP Report on the Toxicity Studies of Perfluorinated Compounds: Carboxylates Administered via Oral Gavage in Hsd: Sprague Dawley SD Rats
Study Data
Toxicity and Carcinogenicity Studies
28-Day Evaluation of the Toxicity (C04049) of Perfluorononanoic Acid (PFNA) (375-95-1) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (17 kB)
- E02 - Animals Removed from Experiment (67 kB)
- E03 - Growth Curves (375 kB)
- E04 - Mean Body Weights and Survival Table (16 kB)
- E05 - Clinical Observations Summary (18 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
- P04 - Neoplasms by Individual Animal (278 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (301 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (166 kB)
- P11 - Statistical Analysis of Survival Data (28 kB)
- P14 - Individual Animal Pathology Data (311 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (277 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (36 kB)
- P40 - Survival Curves (418 kB)
- PA06 - Organ Weights Summary Females (65 kB)
- PA06 - Organ Weights Summary Males (65 kB)
- PA41 - Clinical Chemistry Summary Females (129 kB)
- PA41 - Clinical Chemistry Summary Males (129 kB)
- PA43 - Hematology Summary Females (103 kB)
- PA43 - Hematology Summary Males (135 kB)
- PA45 - Liver Special Studies Summary (31 kB)
- PA48 - Summary of Tissue Concentration Males (52 kB)
- PA48 - Summary of Tissue Concentration Females (40 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary Females (38 kB)
- R07 - Hormone Summary Males (38 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (47 kB)
- Summary of Estrous Stages and Cycle Data (54 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (18 kB)
- Female Individual Animal Non Neoplastic Pathology Data (70 kB)
- Female Individual Animal Survival Data (11 kB)
- Female Individual Animal Terminal Body Weight Data (19 kB)
- Female Individual Clinical Observations (8 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data Females (10 kB)
- Individual Animal Clinical Chemistry Data Males (10 kB)
- Individual Animal Hematology Data Females (11 kB)
- Individual Animal Hematology Data Males (11 kB)
- Individual Animal Hormone Data Females (7 kB)
- Individual Animal Hormone Data Males (7 kB)
- Individual Animal Liver Special Studies Data (6 kB)
- Individual Animal Organ Weight Data Females (8 kB)
- Individual Animal Organ Weight Data Males (8 kB)
- Individual Animal Tissue Concentration Data Females (7 kB)
- Individual Animal Tissue Concentration Data Males (7 kB)
- Individual Vaginal Cytology Data (23 kB)
- Individual_Animal_PCR_Data (20 kB)
- Male Individual Animal Body Weight Data (18 kB)
- Male Individual Animal Non Neoplastic Pathology Data (148 kB)
- Male Individual Animal Survival Data (11 kB)
- Male Individual Animal Terminal Body Weight Data (19 kB)
- Male Individual Clinical Observations (11 kB)
28-Day Evaluation of the Toxicity (C20613) of Perfluorohexanoic acid (PFHXA) (307-24-4) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (67 kB)
- E03 - Growth Curves (391 kB)
- E04 - Mean Body Weights and Survival Table (16 kB)
- E05 - Clinical Observations Summary (18 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (32 kB)
- P04 - Neoplasms by Individual Animal (217 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (237 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (136 kB)
- P11 - Statistical Analysis of Survival Data (27 kB)
- P14 - Individual Animal Pathology Data (280 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (218 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (33 kB)
- P40 - Survival Curves (393 kB)
- PA06 - Organ Weights Summary (117 kB)
- PA41 - Clinical Chemistry Summary (308 kB)
- PA43 - Hematology Summary (276 kB)
- PA45 - Liver Special Studies Summary (36 kB)
- PA48 - Summary of Tissue Concentration (72 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary (68 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (44 kB)
- Summary of Estrous Stages and Cycle Data (54 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (18 kB)
- Female Individual Animal Non Neoplastic Pathology Data (44 kB)
- Female Individual Animal Survival Data (11 kB)
- Female Individual Animal Terminal Body Weight Data (19 kB)
- Female Individual Clinical Observations (2 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data (16 kB)
- Individual Animal Hematology Data (18 kB)
- Individual Animal Hormone Data (11 kB)
- Individual Animal Liver Special Studies Data (6 kB)
- Individual Animal Organ Weight Data (15 kB)
- Individual Animal Tissue Concentration Data (10 kB)
- Individual Vaginal Cytology Data (24 kB)
- Individual_Animal_PCR_Data (25 kB)
- Male Individual Animal Body Weight Data (18 kB)
- Male Individual Animal Neoplastic Pathology Data (2 kB)
- Male Individual Animal Non Neoplastic Pathology Data (50 kB)
- Male Individual Animal Survival Data (11 kB)
- Male Individual Clinical Observations (3 kB)
28-Day Evaluation of the Toxicity (C20615) of Perfluorodecanoic Acid (PFDA) (335-76-2) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (67 kB)
- E03 - Growth Curves (371 kB)
- E04 - Mean Body Weights and Survival Table (16 kB)
- E05 - Clinical Observations Summary (14 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
- P04 - Neoplasms by Individual Animal (225 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (35 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (238 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (154 kB)
- P11 - Statistical Analysis of Survival Data (27 kB)
- P14 - Individual Animal Pathology Data (282 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (224 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 kB)
- P40 - Survival Curves (417 kB)
- PA06 - Organ Weights Summary (118 kB)
- PA41 - Clinical Chemistry Summary (307 kB)
- PA43 - Hematology Summary (276 kB)
- PA45 - Liver Special Studies Summary (36 kB)
- PA48 - Summary of Tissue Concentration (73 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary (68 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (42 kB)
- Summary of Estrous Stages and Cycle Data (59 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (18 kB)
- Female Individual Animal Non Neoplastic Pathology Data (46 kB)
- Female Individual Animal Survival Data (11 kB)
- Female Individual Animal Terminal Body Weight Data (19 kB)
- Female Individual Clinical Observations (2 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data (16 kB)
- Individual Animal Hematology Data (18 kB)
- Individual Animal Hormone Data (12 kB)
- Individual Animal Liver Special Studies Data (6 kB)
- Individual Animal Organ Weight Data (15 kB)
- Individual Animal Tissue Concentration Data (10 kB)
- Individual Vaginal Cytology Data (23 kB)
- Individual_Animal_PCR_Data (24 kB)
- Male Individual Animal Body Weight Data (18 kB)
- Male Individual Animal Non Neoplastic Pathology Data (74 kB)
- Male Individual Animal Survival Data (11 kB)
- Male Individual Animal Terminal Body Weight Data (19 kB)
- Male Individual Clinical Observations (4 kB)
28-Day Evaluation of the Toxicity (C91070B) of Perfluorooctanoic Acid (PFOA) (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (67 kB)
- E03 - Growth Curves (365 kB)
- E04 - Mean Body Weights and Survival Table (16 kB)
- E05 - Clinical Observations Summary (18 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (36 kB)
- P04 - Neoplasms by Individual Animal (218 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (250 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (184 kB)
- P11 - Statistical Analysis of Survival Data (27 kB)
- P14 - Individual Animal Pathology Data (282 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (220 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 kB)
- P40 - Survival Curves (402 kB)
- PA06 - Organ Weights Summary Females (70 kB)
- PA06 - Organ Weights Summary Males (71 kB)
- PA41 - Clinical Chemistry Summary Females (164 kB)
- PA41 - Clinical Chemistry Summary Males (164 kB)
- PA43 - Hematology Summary Females (148 kB)
- PA43 - Hematology Summary Males (148 kB)
- PA45 - Liver Special Studies Summary Males (36 kB)
- PA48 - Summary of Tissue Concentration Males (54 kB)
- PA48 - Summary of Tissue Concentration Females (42 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary Females (46 kB)
- R07 - Hormone Summary Males (46 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (49 kB)
- Summary of Estrous Stages and Cycle Data (59 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (18 kB)
- Female Individual Animal Non Neoplastic Pathology Data (55 kB)
- Female Individual Animal Survival Data (11 kB)
- Female Individual Animal Terminal Body Weight Data (19 kB)
- Female Individual Clinical Observations (3 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data Females (10 kB)
- Individual Animal Clinical Chemistry Data Males (11 kB)
- Individual Animal Hematology Data Females (12 kB)
- Individual Animal Hematology Data Males (12 kB)
- Individual Animal Hormone Data Females (8 kB)
- Individual Animal Hormone Data Males (8 kB)
- Individual Animal Liver Special Studies Data (6 kB)
- Individual Animal Organ Weight Data Females (9 kB)
- Individual Animal Organ Weight Data Males (9 kB)
- Individual Animal PCR Data (25 kB)
- Individual Animal Tissue Concentration Data Females (7 kB)
- Individual Animal Tissue Concentration Data Males (7 kB)
- Individual Vaginal Cytology Data (24 kB)
- Male Individual Animal Body Weight Data (18 kB)
- Male Individual Animal Non Neoplastic Pathology Data (63 kB)
- Male Individual Animal Survival Data (11 kB)
- Male Individual Animal Terminal Body Weight Data (19 kB)
- Male Individual Clinical Observations (3 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Perfluorodecanoic Acid (335-76-2) in Micronucleus Study G92006 in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Perfluorodecanoic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A10025
Summary Data
- G06 - Ames Summary Data (81 KB)
Genetic Toxicity Evaluation of Perfluorohexanoic Acid (PFHXA) (307-24-4) in Micronucleus Study G04048 in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Perfluorohexanoic Acid (PFHXA) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A97455
Summary Data
- G06 - Ames Summary Data (77 KB)
Genetic Toxicity Evaluation of Perfluorononanoic Acid (375-95-1) in Micronucleus Study G04049 in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Perfluorononanoic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A59563
Summary Data
- G06 - Ames Summary Data (82 KB)
Genetic Toxicity Evaluation of Perfluorooctanoic Acid (335-67-1) in DNA Damage Study G91070B in Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Perfluorooctanoic Acid (335-67-1) in Micronucleus Study G91070 in Harlan Sprague-Dawley Rats
Genetic Toxicity Evaluation of Perfluorooctanoic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A98283
Other NTP Studies
Evaluation (500-009-001-000-5) of the Effect of PFAS and PFAS Mixtures (335-67-1, 375-85-9, 2706-90-3) on Endometrial Cancer Cell Lines response to Platinum Based Chemotherapy
Supplemental Materials
- 10.10.2023 Supplemental Figures.docx (67 mB)
- CEBS Endometrial Cancer PFAS Chemotherapy Response Manuscript Environ Health.pzfx (3 mB)
- Environ Health Endometrial Cancer Manuscript SuppMat Data.xlsx (71 kB)
- PDT-analysis_20230113[21].html (988 kB)
- PDT-analysis_20230531ab[45].html (953 kB)
- PDT-analysis_20230531c[13].html (973 kB)
Figures
- Figure - CEBS Endometrial Cancer PFAS Chemotherapy Response Manuscript Environ Health.pzfx (3 mB)
- Figure - Environ Health Endometrial Cancer Manuscript Data.xlsx (126 kB)
- Figure 1 - 09182023.tif (18 mB)
- Figure 1 - CEBS Endometrial Cancer PFAS Chemotherapy Response Manuscript Environ Health.pzfx (3 mB)
- Figure 1 - Environ Health Endometrial Cancer Manuscript Data.xlsx (126 kB)
- Figure 2 - 09182023.tif (17 mB)
- Figure 2 - CEBS Endometrial Cancer PFAS Chemotherapy Response Manuscript Environ Health.pzfx (3 mB)
- Figure 2 - Environ Health Endometrial Cancer Manuscript Data.xlsx (126 kB)
- Figure 3 - 09182023.tif (19 mB)
- Figure 3 - CEBS Endometrial Cancer PFAS Chemotherapy Response Manuscript Environ Health.pzfx (3 mB)
- Figure 3 - Environ Health Endometrial Cancer Manuscript Data.xlsx (126 kB)
- Figure 4 - 10.10.2023.tif (30 mB)
- Figure 4 - CEBS Endometrial Cancer PFAS Chemotherapy Response Manuscript Environ Health.pzfx (3 mB)
- Figure 4 - Environ Health Endometrial Cancer Manuscript Data.xlsx (126 kB)
- Figure 5 - 07312023.tif (31 mB)
- Figure 5 - CEBS Endometrial Cancer PFAS Chemotherapy Response Manuscript Environ Health.pzfx (3 mB)
- Figure 5 - Environ Health Endometrial Cancer Manuscript Data.xlsx (126 kB)
- Figure 6 - 07312023.tif (31 mB)
- Figure 6 - CEBS Endometrial Cancer PFAS Chemotherapy Response Manuscript Environ Health.pzfx (3 mB)
- Figure 6 - Environ Health Endometrial Cancer Manuscript Data.xlsx (126 kB)
Toxicokinetic Evaluation (C20614) of Perfluorooctanoic Acid (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Gavage or Intravenous Injection
Toxicokinetic Evaluation (C20615) of Perfluorodecanoic Acid (335-76-2) in Harlan Sprague-Dawley Rats Exposed via Intravenous Injection and Gavage
Toxicokinetic Evaluation (K10075) of Perfluorooctanoic Acid (DTXSID8031865) in Rat
Toxicokinetic Evaluation (K10128) of Perfluorohexanoic acid (DTXSID3031862) in Rat
Toxicokinetic Evaluation (K10214) of Perfluorodecanoic Acid (DTXSID3031860) in Rat
Data
- Annotated Group Parameters (19 kB)
- Annotated Individual Animal Data (122 kB)
- Original Data (41 kB)
- Summary Data (238 kB)