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2-Nitro-p-phenylenediamine (5307-14-2)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020957

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 2-Nitro-p-phenylenediamine (5307-14-2).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2-Nitro-p-phenylenediamine (5307-14-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2-Nitro-p-phenylenediamine (5307-14-2).
Bacterial Mutagenicity
View
  • Positive

Citation Information

NTP. 2-Nitro-p-phenylenediamine (5307-14-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-169 Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CASRN 5307-14-2)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 2-Nitro-p-phenylenediamine (5307-14-2) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2-Nitro-p-phenylenediamine (5307-14-2) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 2-Nitro-p-phenylenediamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 987998
Summary Data

DTT Data Collections