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Nitrofurantoin (67-20-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7020972

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Nitrofurantoin (67-20-9).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Nitrofurantoin (67-20-9).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Nitrofurantoin (67-20-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Nitrofurantoin (67-20-9).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Nitrofurantoin (67-20-9).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Positive

Citation Information

NTP. Nitrofurantoin (67-20-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-341 Toxicology and Carcinogenesis Studies of Nitrofurantoin (CASRN 67-20-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity (C55196) of Nitrofurantoin (67-20-9) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55196) of Nitrofurantoin (67-20-9) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Nitrofurantoin (67-20-9) in Micronucleus Study A51689 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Nitrofurantoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 131452
Summary Data
Genetic Toxicity Evaluation of Nitrofurantoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 133668
Summary Data
Genetic Toxicity Evaluation of Nitrofurantoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 451594
Summary Data
Genetic Toxicity Evaluation of Nitrofurantoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 626123
Summary Data
Genetic Toxicity Evaluation of Nitrofurantoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 674104
Summary Data
Genetic Toxicity Evaluation of Nitrofurantoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 962072
Summary Data
Genetic Toxicity Evaluation of Nitrofurantoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 981362
Summary Data

NTP Data Collections