U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Benzene (71-43-2)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3039242

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Male, Rats
View
  • Clear Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Male, Mice
View
  • Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Benzene (71-43-2).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Benzene (71-43-2).
Micronucleus - Mice
View
  • Male: Positive
View
  • Male: Positive
View
  • Male: Positive
    Female: Weakly Positive
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
View
  • Male: Positive
    Female: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Benzene (71-43-2).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Benzene (71-43-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Benzene (71-43-2).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Benzene (71-43-2).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Benzene (71-43-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-289 Toxicology and Carcinogenesis Studies of Benzene (CASRN 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutation Res. Vol. 521 (2002) 201 - 208
Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
GMM-08 Toxicology and Carcinogenesis Study of Benzene (CASRN 71-43-2) in Genetically Modified Haploinsufficient p16Ink4a/p19Arf Mice (Gavage Study)
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193

Study Data

Protocol

Toxicity and Carcinogenicity Studies

26-Week Evaluation of the Toxicity (C99034) of Transgenic Model II (Benzene) (71-43-2) in Tg.P16-INK4A Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Benzene (71-43-2) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Benzene (71-43-2) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Benzene (71-43-2) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Benzene (71-43-2) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Benzene (71-43-2) in Micronucleus Study 516923 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Benzene (71-43-2) in Micronucleus Study A32658 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Benzene (71-43-2) in Micronucleus Study A38322 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Benzene (71-43-2) in Micronucleus Study A48141 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Benzene (71-43-2) in Micronucleus Study A53968 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Benzene (71-43-2) in Micronucleus Study A60851 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Benzene (71-43-2) in Micronucleus Study A65367 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Benzene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 085245
Summary Data

Other NTP Studies

ADME/TK Evaluation (S0618) of Benzene (71-43-2) in F344 Rats, B6C3F1 Mice and LVG Golden Syrian Hamsters Exposed via Gavage or Intraperitoneal Injection
Data Summary

NTP Data Collections