Phenolphthalein (77-09-8)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0021125
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
| Rodent Cytogenetics |
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| Micronucleus - Mice |
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| Mammalian Cell Cytogenetics | |
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| CA | SCE |
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| Bacterial Mutagenicity |
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Publications
TR-465
Toxicology and Carcinogenesis Studies of Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
GMM-12
Toxicology and Carcinogenesis Study of Phenolphthalein (CASRN 77-09-8) in Genetically Modified Haploinsufficient p16Ink4a/p19Arf Mice
Study Data
Toxicity and Carcinogenicity Studies
26-Week Evaluation of the Toxicity (C99036) of Transgenic Model II (Phenolphthalein) (77-09-8) in Tg.P16-INK4A Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C55798) of Phenolphthalein (77-09-8) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C55798) of Phenolphthalein (77-09-8) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C55798B) of Phenolphthalein (77-09-8) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C55798B) of Phenolphthalein (77-09-8) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
1-Year Evaluation of the Toxicity (C55798C) of Transgenic Model (Phenolphthalein) (77-09-8) in P53(C57BL/6) Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A13109 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A20259 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A34828 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A93351 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A93723 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A93901 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 041772
Summary Data
- G06 - Ames Summary Data (143 KB)
Genetic Toxicity Evaluation of Phenolphthalein in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 768193
Summary Data
- G06 - Ames Summary Data (138 KB)
Genetic Toxicity Evaluation of Phenolphthalein in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A71314
Summary Data
- G06 - Ames Summary Data (223 KB)
Genetic Toxicity Evaluation of Phenolphthalein in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A99430
Summary Data
- G06 - Ames Summary Data (228 KB)
Other NTP Studies
Toxicokinetic Evaluation (S0594) of Phenolphthalein (DTXSID0021125) in Rat and Mouse
Data
- Annotated Group Parameters (26 kB)
- Annotated Individual Animal Data (598 kB)
- Original Data (200 kB)
- Summary Data - Mice (228 kB)
- Summary Data - Rats (189 kB)