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Phenolphthalein (77-09-8)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0021125

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Male, Rats
  • Some Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Phenolphthalein (77-09-8).
Rodent Cytogenetics
CA
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Phenolphthalein (77-09-8).
Micronucleus - Mice
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Phenolphthalein (77-09-8).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Phenolphthalein (77-09-8).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Equivocal

Citation Information

NTP. Phenolphthalein (77-09-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-465 Toxicology and Carcinogenesis Studies of Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
GMM-12 Toxicology and Carcinogenesis Study of Phenolphthalein (CASRN 77-09-8) in Genetically Modified Haploinsufficient p16Ink4a/p19Arf Mice

Study Data

Protocol

Toxicity and Carcinogenicity Studies

26-Week Evaluation of the Toxicity (C99036) of Transgenic Model II (Phenolphthalein) (77-09-8) in Tg.P16-INK4A Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C55798) of Phenolphthalein (77-09-8) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C55798) of Phenolphthalein (77-09-8) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55798B) of Phenolphthalein (77-09-8) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55798B) of Phenolphthalein (77-09-8) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
1-Year Evaluation of the Toxicity (C55798C) of Transgenic Model (Phenolphthalein) (77-09-8) in P53(C57BL/6) Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A13109 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A20259 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A34828 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A93351 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A93723 in P16(INK4A)/(+/-) (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein (77-09-8) in Micronucleus Study A93901 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Phenolphthalein in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 041772
Summary Data
Genetic Toxicity Evaluation of Phenolphthalein in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 768193
Summary Data
Genetic Toxicity Evaluation of Phenolphthalein in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A71314
Summary Data
Genetic Toxicity Evaluation of Phenolphthalein in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A99430
Summary Data

Other NTP Studies

Toxicokinetic Evaluation (S0594) of Phenolphthalein (DTXSID0021125) in Rat and Mouse
Data

DTT Data Collections