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Isophorone (78-59-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8020759

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Some Evidence, Male, Rats
View
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Equivocal Evidence, Male, Mice
View
  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Isophorone (78-59-1).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Isophorone (78-59-1).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Isophorone (78-59-1).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Isophorone (78-59-1).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Isophorone (78-59-1).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Isophorone (78-59-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-291 Toxicology and Carcinogenesis Studies of Isophorone (CASRN 78-59-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Isophorone (78-59-1) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Isophorone (78-59-1) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Isophorone (78-59-1) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Isophorone (78-59-1) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Isophorone in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 505090
Summary Data

NTP Data Collections