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4-Methylimidazole (822-36-6)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Equivocal Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to 4-Methylimidazole (822-36-6).
Micronucleus - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 4-Methylimidazole (822-36-6).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 4-Methylimidazole (822-36-6).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information


NTP. 4-Methylimidazole (822-36-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-535 Toxicology and Carcinogenesis Studies of 4-Methylimidazole (CASRN 822-36-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
TOX-67 Toxicity Studies of 2-Methylimidazole and 4-Methylimidazole Administered in Feed to F344/N Rats and B6C3F1Mice (CASRN 693-98-1 and 822-36-6)
Multigenerational reproductive assessment of 4-methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats Mamta Behl, Cynthia J Willson, Helen Cunny, Paul M D Foster, Barry McIntyre, Cynthia Shackelford, Keith R Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha, Chad R Blystone

Reproductive Toxicology (2020) DOI: https://doi.org/10.1016/j.reprotox.2020.03.005 PMID: 32229253
DOI: https://doi.org/10.22427/NTP-DATA-002-01511-0000-0000-0


Study Data


Toxicity and Carcinogenicity Studies


2-Week Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in F344 Rats Exposed via Dosed Feed. NTP Special Study
2-Week Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in B6C3F1 Mice Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C92013B) of 4-Methylimidazole (822-36-6) in F344/N Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C92013B) of 4-Methylimidazole (822-36-6) in B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 4-Methylimidazole (822-36-6) in Micronucleus Study A12637 in B6C3F1 Mice
Genetic Toxicity Evaluation of 4-Methylimidazole (822-36-6) in Micronucleus Study A38684 in F344 Rats
Genetic Toxicity Evaluation of 4-Methylimidazole (822-36-6) in Micronucleus Study A49564 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 4-Methylimidazole in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A41578
Summary Data
Genetic Toxicity Evaluation of 4-Methylimidazole in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A53668
Summary Data

Other NTP Studies


Reproductive Assessment Through Continuous Breeding Dose Range Finding Toxicity Study (R92025) of 4-Methylimidazole (822-36-6) in Sprague-Dawley Rats Exposed via Dosed Feed
Reproductive Assessment Through Continuous Breeding Toxicity Study (R92025B) of 4-Methylimdazole (822-36-6) in Sprague Dawley Rats Exposed via Dosed Feed
Study Tables
Individual Animal Data
Toxicokinetic Evaluation (C92013B) of 4-Methylimidazole (822-36-6) in F344/N Rats and B6C3F1 Mice Exposed via Gavage or Intravenous Injection (Amended Report)