4-Methylimidazole (822-36-6)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID9025617
Study Results
Chronic Bioassay Level of Evidence
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| Micronucleus - Rats |
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| Bacterial Mutagenicity |
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Publications
TR-535
Toxicology and Carcinogenesis Studies of 4-Methylimidazole (CASRN 822-36-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
TOX-67
Toxicity Studies of 2-Methylimidazole and 4-Methylimidazole Administered in Feed to F344/N Rats and B6C3F1Mice (CASRN 693-98-1 and 822-36-6)
Multigenerational reproductive assessment of 4-methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats
Mamta Behl, Cynthia J Willson, Helen Cunny, Paul M D Foster, Barry McIntyre, Cynthia Shackelford, Keith R Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha, Chad R Blystone
Reproductive Toxicology (2020) DOI: https://doi.org/10.1016/j.reprotox.2020.03.005 PMID: 32229253
DOI: https://doi.org/10.22427/NTP-DATA-002-01511-0000-0000-0
Reproductive Toxicology (2020) DOI: https://doi.org/10.1016/j.reprotox.2020.03.005 PMID: 32229253
DOI: https://doi.org/10.22427/NTP-DATA-002-01511-0000-0000-0
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in F344 Rats Exposed via Dosed Feed. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
2-Week Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C92013) of 4-Methylimidazole (822-36-6) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C92013B) of 4-Methylimidazole (822-36-6) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C92013B) of 4-Methylimidazole (822-36-6) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 4-Methylimidazole (822-36-6) in Micronucleus Study A12637 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 4-Methylimidazole (822-36-6) in Micronucleus Study A38684 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 4-Methylimidazole (822-36-6) in Micronucleus Study A49564 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 4-Methylimidazole in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A41578
Summary Data
- G06 - Ames Summary Data (127 KB)
Genetic Toxicity Evaluation of 4-Methylimidazole in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A53668
Summary Data
- G06 - Ames Summary Data (143 KB)
Other NTP Studies
Reproductive Assessment Through Continuous Breeding Dose Range Finding Toxicity Study (R92025) of 4-Methylimidazole (822-36-6) in Sprague-Dawley Rats Exposed via Dosed Feed
Study Tables
- I01 - Animal Removal Summary (52 kB)
- I02 - Animal Removals (317 kB)
- I03 - Growth Curve (183 kB)
- I04 - Mean Body Weights (366 kB)
- I04G - Mean Body Weight Gain (87 kB)
- I05 - Clinical Observationss Summary (164 kB)
- I05P - Pup Clinical Observations Summary (237 kB)
- I06 - Mean Feed Consumption (297 kB)
- I08 - Mean Test Compound Consumption (224 kB)
- PA46 - Gross Pathology Summary (105 kB)
- R01 - Multigeneration Cross Reference (731 kB)
- R02 - Reproductive Performance Summary (45 kB)
- R03 - Litter Data Summary (62 kB)
- R19 - Pup Mean Body Weight Summary (156 kB)
- R19G - Pup Mean Body Weight Gain (135 kB)
- R20 - Pup Necropsy Summary (61 kB)
Individual Animal Data
- Individual Animal Body Weight Data (69 kB)
- Individual Animal Clinical Observations Data (188 kB)
- Individual Animal Consumption Data (87 kB)
- Individual Animal Gross Pathology Data (5 kB)
- Individual Animal Litter Data (36 kB)
- Individual Animal Pup Body Weight Data (57 kB)
- Individual Animal Pup Clinical Observations Data (282 kB)
- Individual Animal Pup Necropsy Data (5 kB)
- Individual Animal Removal Reasons Data (7 kB)
- Individual Animal Reproductive Performance Data (7 kB)
Reproductive Assessment Through Continuous Breeding Toxicity Study (R92025B) of 4-Methylimdazole (822-36-6) in Sprague Dawley Rats Exposed via Dosed Feed
Study Tables
- I01 - Animal Removal Summary (178 kB)
- I02 - Animal Removals (5 mB)
- I03 - Growth Curve (788 kB)
- I04 - Mean Body Weight Summary (1 mB)
- I04G - Mean Body Weight Gain (342 kB)
- I05 - Clinical Observations Summary (2 mB)
- I05P - Pup Clinical Observations Summary (942 kB)
- I06 - Mean Feed Consumption (777 kB)
- I08 - Mean Test Compound Consumption (578 kB)
- I23 - Average Dose by Phase (81 kB)
- PA02R - Neoplastic Lesion Summary with Percent and Litter Incidence (778 kB)
- PA03R - Non-Neoplastic Lesion Summary with Percent and Litter Incidence (942 kB)
- PA05R - Incidence Rates of Neoplastic Lesions with Litter Incidence Systemic Lesions Abridged (769 kB)
- PA06R - Organ Weights Summary (245 kB)
- PA08R - Statistical Analysis of Neoplastic Lesions with Litter Incidence (629 kB)
- PA10R - Statistical Analysis of Non-Neoplastic Lesions with Litter Incidence (894 kB)
- PA11 - Statistical Analysis of Survival Data (420 kB)
- PA14 - Individual Animal Pathology Data (9 mB)
- PA18R - Non-Neoplastic Lesion Summary with Severity Grade and Litter Incidence (943 kB)
- PA23 - Ovarian Follicles Summary (93 kB)
- PA40 - Survival Curve (1 mB)
- PA46R - Summary of Gross Pathology with Litter Incidence (1 mB)
- R01 - Multigeneration Cross Reference (12 mB)
- R02 - Reproductive Performance Summary (148 kB)
- R03 - Litter Data Summary (219 kB)
- R04 - Anogenital Distance Summary (123 kB)
- R06 - Andrology Summary (102 kB)
- R14 - Developmental Markers Summary (141 kB)
- R16 - Pubertal Markers Summary (156 kB)
- R19 - Pup Mean Body Weight Summary (674 kB)
- R19G - Pup Mean Body Weight Gain (472 kB)
- R20 - Pup Necropsy Summary (702 kB)
- R21 - Cross Generational Summary of Reproductive Performance (62 kB)
- R22 - Cross Generational Summary of Litters (70 kB)
Individual Animal Data
- Individual Animal Andrology Data (35 kB)
- Individual Animal Body Weight Data (1 mB)
- Individual Animal Clinical Observations Data (4 mB)
- Individual Animal Consumption Data (1 mB)
- Individual Animal Developmental Markers Data (396 kB)
- Individual Animal Gross Pathology Data (534 kB)
- Individual Animal Histo Pathology Data (329 kB)
- Individual Animal Litter Crossover Data (20 kB)
- Individual Animal Litter Data (307 kB)
- Individual Animal Organ Weight Data (91 kB)
- Individual Animal Pup Body Weight Data (698 kB)
- Individual Animal Pup Clinical Observations Data (3 mB)
- Individual Animal Pup Necropsy Data (42 kB)
- Individual Animal Removal Reasons Data (55 kB)
- Individual Animal Reproductive Performance Crossover Data (9 kB)
- Individual Animal Reproductive Performance Data (29 kB)