COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Pulegone (89-82-7)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Male, Rats
  • Some Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Pulegone (89-82-7).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Pulegone (89-82-7).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative
View
  • Positive

Citation Information


NTP. Pulegone (89-82-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-563 Toxicology and Carcinogenesis Studies of Pulegone (CASRN 89-82-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Study Data


Toxicity and Carcinogenicity Studies


2-Week Evaluation of the Toxicity (C99020) of Pulegone (89-82-7) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C99020) of Pulegone (89-82-7) in F344 Rats Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C99020) of Pulegone (89-82-7) in F344 Rats Exposed via Gavage. NTP Special Study
2-Week Evaluation of the Toxicity (C99020) of Pulegone (89-82-7) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C99020) of Pulegone (89-82-7) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C99020) of Pulegone (89-82-7) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C99020) of Pulegone (89-82-7) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C99020) of Pulegone (89-82-7) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C99020) of Pulegone (89-82-7) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C99020) of Pulegone (89-82-7) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C99020) of Pulegone (89-82-7) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C99020) of Pulegone (89-82-7) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Pulegone (89-82-7) in Micronucleus Study A36729 in B6C3F1 Mice
Genetic Toxicity Evaluation of Pulegone in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A17590
Summary Data
Genetic Toxicity Evaluation of Pulegone in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A65321
Summary Data
Genetic Toxicity Evaluation of Pulegone in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G98045
Summary Data