1,2-Dichlorobenzene (95-50-1)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6020430
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
Rodent Cytogenetics | |
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CA | SCE |
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Micronucleus - Mice |
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Mammalian Cell Mutagenicity |
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Mammalian Cell Cytogenetics | |
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CA | SCE |
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Drosophila Germ Cell Mutagenicity |
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SLRL |
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Bacterial Mutagenicity |
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Publications
TR-255
Toxicology and Carcinogenesis Studies of 1,2-Dichlorobenzene (o-Dichlorobenzene) (CASRN 95-50-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
Study Data
Toxicity and Carcinogenicity Studies
6 - 48-Hour Evaluation of the Toxicity (C20412) of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in F344/N Rats Exposed via Gavage. NTP Special Study
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Female B6C3F1 Mice Exposed via Gavage
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Micronucleus Study 279592 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Micronucleus Study 749046 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Micronucleus Study A44739 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,2-Dichlorobenzene (o-Dichlorobenzene) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 917014
Summary Data
- G06 - Ames Summary Data (125 KB)