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1,2-Dichlorobenzene (95-50-1)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 1,2-Dichlorobenzene (95-50-1).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,2-Dichlorobenzene (95-50-1).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,2-Dichlorobenzene (95-50-1).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,2-Dichlorobenzene (95-50-1).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1,2-Dichlorobenzene (95-50-1).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,2-Dichlorobenzene (95-50-1).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. 1,2-Dichlorobenzene (95-50-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-255 Toxicology and Carcinogenesis Studies of 1,2-Dichlorobenzene (o-Dichlorobenzene) (CASRN 95-50-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303

Study Data


Toxicity and Carcinogenicity Studies


6 - 48-Hour Evaluation of the Toxicity (C20412) of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in F344/N Rats Exposed via Gavage. NTP Special Study
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Female B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Micronucleus Study 279592 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Micronucleus Study 749046 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,2-Dichlorobenzene (o-Dichlorobenzene) (95-50-1) in Micronucleus Study A44739 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,2-Dichlorobenzene (o-Dichlorobenzene) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 917014
Summary Data