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1,2-Dibromo-3-chloropropane (96-12-8)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3020413

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Positive, Male, Rats
View
  • Positive, Male, Rats
View
  • Positive, Female, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 1,2-Dibromo-3-chloropropane (96-12-8).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,2-Dibromo-3-chloropropane (96-12-8).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,2-Dibromo-3-chloropropane (96-12-8).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,2-Dibromo-3-chloropropane (96-12-8).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1,2-Dibromo-3-chloropropane (96-12-8).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,2-Dibromo-3-chloropropane (96-12-8).
Bacterial Mutagenicity
View
  • Positive

Citation Information

NTP. 1,2-Dibromo-3-chloropropane (96-12-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-028 Bioassay of Dibromochloropropane for Possible Carcinogenicity (CASRN 96-12-8)
TR-206 Carcinogenesis Bioassay of 1,2-Dibromo-3-chloropropane (CASRN 96-12-8) in F344 Rats and B6C3F1 Mice (Inhalation Study)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromo-3-chloropropane (96-12-8) in Male F344 Rats via Whole Body Respiratory Exposure
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromo-3-chloropropane (96-12-8) in Female F344 Rats via Whole Body Respiratory Exposure
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromo-3-chloropropane (96-12-8) in Male Osborne-Mendel Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromo-3-chloropropane (96-12-8) in Female Osborne-Mendel Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromo-3-chloropropane (96-12-8) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromo-3-chloropropane (96-12-8) in Male B6C3F1 Mice via Whole Body Respiratory Exposure
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromo-3-chloropropane (96-12-8) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromo-3-chloropropane (96-12-8) in Female B6C3F1 Mice via Whole Body Respiratory Exposure
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 1,2-Dibromo-3-chloropropane (96-12-8) in Micronucleus Study 158710 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,2-Dibromo-3-chloropropane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 197399
Summary Data

NTP Data Collections