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Perfluorooctanoic acid (335-67-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8031865

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Perfluorooctanoic acid (335-67-1).
Micronucleus - Rats
View
  • Male: Positive
    Female: Negative
An overview of Genetic Toxicology In Vivo Alkaline Comet Assay Rats study conclusions related to Perfluorooctanoic acid (335-67-1).
In Vivo Alkaline Comet Assay - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Perfluorooctanoic acid (335-67-1).
Bacterial Mutagenicity
View
  • Equivocal

Citation Information

NTP. Perfluorooctanoic acid (335-67-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-598 Toxicology and Carcinogenesis Studies of Perfluorooctanoic Acid Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats
TOX-97 NTP Report on the Toxicity Studies of Perfluorinated Compounds: Carboxylates Administered via Oral Gavage in Hsd: Sprague Dawley SD Rats
The Mammary Gland is a Sensitive Pubertal Target in CD-1 and C57Bl/6 Mice Following Perinatal Perfluorooctanoic Acid (PFOA) Exposure Tucker DK, Macon MB, Strynar MJ, Dagnino S, Andersen E, Fenton SE.
Reprod Toxicol (2015) DOI: https://doi.org/10.1016/j.reprotox.2014.12.002 PMID:30496566
Chronic PFAS Exposure Induces Chemotherapy Resistance by Promoting Mitochondria-Related Alterations in Ovarian Cancer Cells Brittany P. Rickard, Lauren A. Sapienza Lundie, Marta Overchuk, Justin Tulino, Mateus Prates Mori, James P. McCord, Vesna A. Chappell, Carl D. Bortner, Victoria L. Bae-Jump, Janine H. Santos, Suzanne E. Fenton, Imran Rizvi

Publication DOI: https://doi.org/10.1016/j.envres.2025.122211
DOI: https://doi.org/10.22427/NTP-DATA-500-109-001-000-6
A high-throughput toxicity screen of 42 per- and polyfluoroalkyl substances (PFAS) and functional assessment of migration and gene expression in human placental trophoblast cells Bevin E. Blake, Brittany P. Rickard, and Suzanne E. Fenton
DOI: https://doi.org/10.22427/NTP-DATA-025-00001-0001-000-9
Repeat 5-day in vivo genomic dose response studies Fred Parham, Michele R Balik-Meisner, William M Gwinn, Matthew D Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, Bruce Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R Shah, Deepak Mav, Dhiral P Phadke, Georgia Roberts, Michael J DeVito, Scott S Auerbach

DOI: https://doi.org/10.22427/NTP-DATA-002-00099-0001-000-1

BioProject ID: PRJNA926950
Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation Harlie A. Cope, Bevin E. Blake, Charlotte Love, James McCord, Susan A. Elmore, Janice B. Harvey, Vesna A. Chappell, Suzanne E. Fenton
Science Direct (2021) https://doi.org/10.1016/j.emcon.2021.10.004 PMID: 35097227
DOI: https://doi.org/10.22427/NTP-DATA-002-02657-0013-0000-6
Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX) Bevin E. Blake, Harlie A. Cope, Samantha M. Hall, Robert D. Keys, Beth W. Mahler, James McCord, Brittany Scott, Heather M. Stapleton, Mark J. Strynar, Susan A. Elmore, Suzanne E. Fenton
Environmental Health Perspectives(2020) DOI: https://doi.org/10.1289/EHP6233 PMID: 32074459 PMCID: PMC7064328
DOI: https://doi.org/10.22427/NTP-DATA-021-00006-0001-0000-0
Exposure to Select PFAS and PFAS Mixtures Alters Response to Platinum-Based Chemotherapy in Endometrial Cancer Cell Lines Brittany P. Rickard, Marta Overchuk, Justin Tulino, Xianming Tan, Frances S. Ligler, Victoria L. Bae-Jump, Suzanne E. Fenton, and Imran Rizvi

DOI: https://doi.org/10.22427/NTP-DATA-500-009-001-000-5
Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines Brittany P. Rickard, Xianming Tan, Suzanne E. Fenton, and Imran Rizvi
International Journal of Molecular Sciences (2022), 23(9), 5176; DOI: https://doi.org/10.3390/ijms23095176

DOI: https://doi.org/10.22427/NTP-DATA-025-00001-0002-000-0
Toxicokinetics of Perfluorohexanoic acid (PFHxA), Perfluorooctanoic acid (PFOA), and Perfluorodecanoic Acid (PFDA) in Male and Female Hsd:Sprague Dawley SD Rats following Intravenous or Gavage Administration Dzierlenga A.L, Robinson V.G, Waidyanatha S, DeVito M.J, Eifrid M.A, Gibbs S.T, Granville C.A, *Blystone C.R

DOI: https://doi.org/10.22427/NTP-DATA-002-00037-0002-000-4
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Photodynamic Priming Overcomes Per- and Polyfluoroalkyl Substance (PFAS)-Induced Platinum Resistance in Ovarian Cancer Brittany P Rickard, Xianming Tan, Suzanne E Fenton, Imran Rizvi

Study Data

Protocol

Toxicity and Carcinogenicity Studies

28-Day Evaluation of the Toxicity (C91070B) of Perfluorooctanoic Acid (PFOA) (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
Individual Animal Data
5-day study (C91070C) of perfluorooctanoic acid (335-67-1) delivered via Gavage in HSD Rat
Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C20614) of Perfluorooctanoic Acid (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Interim (16 Week) of Chronic Study One (C20614) – Male and Female Rats
Chronic Study One (C20614) - Male and Female Rats
Chronic Individual Animal Data of Study One (C20614) - Male and Female Rats
Evaluation of the Chronic Toxicity and Carcinogenicity (C20614B) of Perfluorooctanoic Acid (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Interim (16 Week) of Chronic Study Two (C20614B) – Male Rats
Chronic Study Two (C20614B) – Male Rats
Chronic Individual Animal Data of Study Two (C20614B) - Male Rats
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Perfluorooctanoic Acid (335-67-1) in DNA Damage Study G91070B in Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Perfluorooctanoic Acid (335-67-1) in Micronucleus Study G91070 in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Perfluorooctanoic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A98283
Summary Data

Other NTP Studies

Evaluation (500-009-001-000-5) of the Effect of PFAS and PFAS Mixtures (335-67-1, 375-85-9, 2706-90-3) on Endometrial Cancer Cell Lines response to Platinum Based Chemotherapy
Supplemental Materials
Figures
Toxicokinetic Evaluation (C20614) of Perfluorooctanoic Acid (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Gavage or Intravenous Injection
Data
Toxicokinetic Evaluation (K10075) of Perfluorooctanoic Acid (DTXSID8031865) in Rat
Data

DTT Data Collections