COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

4,4'-Methylenebis(2-chloroaniline) (101-14-4)


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 4,4'-Methylenebis(2-chloroaniline) (101-14-4).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 4,4'-Methylenebis(2-chloroaniline) (101-14-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 4,4'-Methylenebis(2-chloroaniline) (101-14-4).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Weakly Positive
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Equivocal

Citation Information


NTP. 4,4'-Methylenebis(2-chloroaniline) (101-14-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52

Study Data


Genetic Toxicology Studies


Genetic Toxicity Evaluation of 4,4'-Methylenebis(2-chloroaniline) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 023975
Summary Data
Genetic Toxicity Evaluation of 4,4'-Methylenebis(2-chloroaniline) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 276143
Summary Data
Genetic Toxicity Evaluation of 4,4'-Methylenebis(2-chloroaniline) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 371964
Summary Data
Genetic Toxicity Evaluation of 4,4'-Methylenebis(2-chloroaniline) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 710935
Summary Data
Genetic Toxicity Evaluation of 4,4'-Methylenebis(2-chloroaniline) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 748170
Summary Data
Genetic Toxicity Evaluation of 4,4'-Methylenebis(2-chloroaniline) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 844170
Summary Data
Genetic Toxicity Evaluation of 4,4'-Methylenebis(2-chloroaniline) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 913572
Summary Data
Genetic Toxicity Evaluation of 4,4'-Methylenebis(2-chloroaniline) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 933484
Summary Data
Genetic Toxicity Evaluation of 4,4'-Methylenebis(2-chloroaniline) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 944170
Summary Data
Genetic Toxicity Evaluation of 4,4'-Methylenebis(2-chloroaniline) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 977612
Summary Data