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1,2-Dibromoethane (106-93-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3020415


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Positive, Male, Rats
View
  • Positive, Male, Rats
View
  • Positive, Female, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 1,2-Dibromoethane (106-93-4).
Rodent Cytogenetics
CA SCE
  • View
    • Positive (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,2-Dibromoethane (106-93-4).
Micronucleus - Mice
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,2-Dibromoethane (106-93-4).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,2-Dibromoethane (106-93-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1,2-Dibromoethane (106-93-4).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,2-Dibromoethane (106-93-4).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. 1,2-Dibromoethane (106-93-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-086 Bioassay of 1,2-Dibromoethane for Possible Carcinogenicity (CASRN 106-93-4)
TR-210 Carcinogenesis Bioassay of 1,2-Dibromoethane (CASRN 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromoethane (106-93-4) in Male F344 Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromoethane (106-93-4) in Female F344 Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromoethane (106-93-4) in Male Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromoethane (106-93-4) in Female Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromoethane (106-93-4) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromoethane (106-93-4) in Male B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromoethane (106-93-4) in Female B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dibromoethane (106-93-4) in Female B6C3F1 Mice via Whole Body Respiratory Exposure