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Acrylonitrile (107-13-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020029


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Acrylonitrile (107-13-1).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Female: Negative
View
  • Female: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Acrylonitrile (107-13-1).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Acrylonitrile (107-13-1).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Acrylonitrile (107-13-1).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Acrylonitrile (107-13-1).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. Acrylonitrile (107-13-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-506 Toxicology and Carcinogenesis Studies of Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage Studies)
Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C50215B) of Acrylonitrile (107-13-1) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C50215B) of Acrylonitrile (107-13-1) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C50215B) of Acrylonitrile (107-13-1) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Acrylonitrile (107-13-1) in Micronucleus Study A56933 in B6C3F1 Mice
Genetic Toxicity Evaluation of Acrylonitrile (107-13-1) in Micronucleus Study A69991 in B6C3F1 Mice
Genetic Toxicity Evaluation of Acrylonitrile (107-13-1) in Micronucleus Study A92525 in B6C3F1 Mice
Genetic Toxicity Evaluation of Acrylonitrile in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 198018
Summary Data