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bis(2-Chloro-1-methylethyl) ether (108-60-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020167

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to bis(2-Chloro-1-methylethyl) ether (108-60-1).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to bis(2-Chloro-1-methylethyl) ether (108-60-1).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to bis(2-Chloro-1-methylethyl) ether (108-60-1).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to bis(2-Chloro-1-methylethyl) ether (108-60-1).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to bis(2-Chloro-1-methylethyl) ether (108-60-1).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Positive
View
  • Weakly Positive

Citation Information

NTP. bis(2-Chloro-1-methylethyl) ether (108-60-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-191 Bioassay of Technical Grade Bis(2-chloro-1-methylethyl) ether for Possible Carcinogenicity (CASRN 108-60-1)
TR-239 Carcinogenesis Bioassay of Bis(2-chloro-1-methylethyl)ether (~70) (CASRN 108-60-1) Containing 2-Chloro-1-methylethyl(2-chloropropyl)ether (~30) (CASRN 83270-31-9) in B6C3F1 Mice (Gavage Study)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of bis(2-Chloro-1-methylethyl) Ether (108-60-1) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of bis(2-Chloro-1-methylethyl) Ether (108-60-1) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of bis(2-Chloro-1-methylethyl) Ether (108-60-1) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of bis(2-Chloro-1-methylethyl) Ether (108-60-1) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of bis(2-Chloro-1-methylethyl) Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 035504
Summary Data
Genetic Toxicity Evaluation of bis(2-Chloro-1-methylethyl) Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 082677
Summary Data
Genetic Toxicity Evaluation of bis(2-Chloro-1-methylethyl) Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 175248
Summary Data
Genetic Toxicity Evaluation of bis(2-Chloro-1-methylethyl) Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 247021
Summary Data
Genetic Toxicity Evaluation of bis(2-Chloro-1-methylethyl) Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 856126
Summary Data
Genetic Toxicity Evaluation of bis(2-Chloro-1-methylethyl) Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 891894
Summary Data

DTT Data Collections