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Furan (110-00-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6020646

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Furan (110-00-9).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Furan (110-00-9).
Micronucleus - Mice
View
  • Female: Equivocal
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Furan (110-00-9).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Furan (110-00-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology In Vivo Alkaline Comet Assay Mice study conclusions related to Furan (110-00-9).
In Vivo Alkaline Comet Assay - Mice
View
  • Female: Positive
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Furan (110-00-9).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Furan (110-00-9).
Bacterial Mutagenicity
View
  • Negative
View
  • Weakly Positive

Citation Information

NTP. Furan (110-00-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-402 Toxicology and Carcinogenesis Studies of Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Repeat 5-day in vivo genomic dose response studies Fred Parham, Michele R Balik-Meisner, William M Gwinn, Matthew D Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, Bruce Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R Shah, Deepak Mav, Dhiral P Phadke, Georgia Roberts, Michael J DeVito, Scott S Auerbach

DOI: https://doi.org/10.22427/NTP-DATA-002-00099-0001-000-1

BioProject ID: PRJNA926950
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Study Data

Protocol

Toxicity and Carcinogenicity Studies

5-Day Evaluation of the Toxicity (C10119B-01) of Furan (110-00-9) on Harlan Sprague-Dawley Rats Exposed via Gavage
Study Table
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C56202) of Furan (110-00-9) in F344/N Rats Exposed via Gavage
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C56202) of Furan (110-00-9) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Furan (110-00-9) in DNA Damage Study G10119C in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Furan (110-00-9) in Micronucleus Study G10119B in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Furan in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 717172
Summary Data
Genetic Toxicity Evaluation of Furan in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 734219
Summary Data

DTT Data Collections