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Glutaraldehyde (111-30-8)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6025355

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Glutaraldehyde (111-30-8).
Rodent Cytogenetics
CA
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Glutaraldehyde (111-30-8).
Micronucleus - Mice
View
  • Male: Equivocal
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Glutaraldehyde (111-30-8).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Glutaraldehyde (111-30-8).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Glutaraldehyde (111-30-8).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Glutaraldehyde (111-30-8).
Bacterial Mutagenicity
View
  • Positive
View
  • Weakly Positive
View
  • Equivocal

Citation Information

NTP. Glutaraldehyde (111-30-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-490 Toxicology and Carcinogenesis Studies of Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
TOX-25 Toxicity Studies of Glutaraldehyde (CASRN 111-30-8) Adminstered by Inhalation to F344/N Rats and B6C3F1Mice.
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
Evaluation of the Respiratory Tract Toxicity of <i>ortho</i>-Phthalaldehyde, a Proposed Alternative for the Chemical Disinfectant Glutaraldehyde Natasha R. Catlin, Cynthia J. Willson, Matthew Stout, Grace E. Kissling, Suramya Waidyanatha, Gregory L. Baker, Barry K. Hayden, Michael Wyde.
Inhalation Toxicology (2017). DOI: https://doi.org/10.1080/08958378.2017.1390015 PMID: 29039228

Study Data

Protocol

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C55425B) of Glutaraldehyde (111-30-8) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
Pathology Tables
Individual Animal Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C55425B) of Glutaraldehyde (111-30-8) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C55425B) of Glutaraldehyde (111-30-8) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C55425B) of Glutaraldehyde (111-30-8) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55425C) of Glutaraldehyde (111-30-8) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55425C) of Glutaraldehyde (111-30-8) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Glutaraldehyde (111-30-8) in Micronucleus Study 212368 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Glutaraldehyde (111-30-8) in Micronucleus Study 462636 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Glutaraldehyde (111-30-8) in Micronucleus Study A57716 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Glutaraldehyde in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 502523
Summary Data
Genetic Toxicity Evaluation of Glutaraldehyde in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 684635
Summary Data
Genetic Toxicity Evaluation of Glutaraldehyde in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 761374
Summary Data

NTP Data Collections