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Titanium dioxide (13463-67-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3021352

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Titanium dioxide (13463-67-7).
Rodent Cytogenetics
CA SCE
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Titanium dioxide (13463-67-7).
Micronucleus - Mice
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Titanium dioxide (13463-67-7).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Titanium dioxide (13463-67-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Titanium dioxide (13463-67-7).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Titanium dioxide (13463-67-7).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Titanium dioxide (13463-67-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-097 Bioassay of Titanium Dioxide for Possible Carcinogenicity (CASRN 13463-67-7)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Titanium Dioxide (13463-67-7) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Titanium Dioxide (13463-67-7) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Titanium Dioxide (13463-67-7) in Male B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Titanium Dioxide (13463-67-7) in Female B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Titanium Dioxide (13463-67-7) in Micronucleus Study 563272 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Titanium Dioxide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 004554
Summary Data

NTP Data Collections