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2,6-Toluenediamine dihydrochloride (15481-70-6)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 2,6-Toluenediamine dihydrochloride (15481-70-6).
Rodent Cytogenetics
CA SCE
  • View
    • Negative (Nonstandard Protocol)
  • View
    • Negative
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 2,6-Toluenediamine dihydrochloride (15481-70-6).
Micronucleus - Mice
View
  • Male: Positive
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 2,6-Toluenediamine dihydrochloride (15481-70-6).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2,6-Toluenediamine dihydrochloride (15481-70-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 2,6-Toluenediamine dihydrochloride (15481-70-6).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2,6-Toluenediamine dihydrochloride (15481-70-6).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. 2,6-Toluenediamine dihydrochloride (15481-70-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-200 Bioassay of 2,6-Toluenediamine Dihydrochloride for Possible Carcinogenicity (CASRN 15481-70-6)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 2,6-Toluenediamine Dihydrochloride (2,6-Diaminotoluene Dihydrochloride) (15481-70-6) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,6-Toluenediamine Dihydrochloride (2,6-Diaminotoluene Dihydrochloride) (15481-70-6) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,6-Toluenediamine Dihydrochloride (2,6-Diaminotoluene Dihydrochloride) (15481-70-6) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,6-Toluenediamine Dihydrochloride (2,6-Diaminotoluene Dihydrochloride) (15481-70-6) in Female B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 2,6-Toluenediamine Dihydrochloride (2,6-Diaminotoluene Dihydrochloride) (15481-70-6) in Micronucleus Study 256727 in B6C3F1 Mice
Genetic Toxicity Evaluation of 2,6-Toluenediamine Dihydrochloride (2,6-Diaminotoluene Dihydrochloride) (15481-70-6) in Micronucleus Study 889785 in B6C3F1 Mice
Genetic Toxicity Evaluation of 2,6-Toluenediamine Dihydrochloride (2,6-Diaminotoluene Dihydrochloride) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 982821
Summary Data