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Isobutyl nitrite (542-56-3)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Some Evidence, Female, Mice
  • Some Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Isobutyl nitrite (542-56-3).
Micronucleus - Mice
View
  • Male: Positive
    Female: Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Isobutyl nitrite (542-56-3).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Isobutyl nitrite (542-56-3).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Isobutyl nitrite (542-56-3).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive
View
  • Positive

Citation Information


NTP. Isobutyl nitrite (542-56-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-448 Toxicology and Carcinogenesis Studies of Isobutyl Nitrite (CASRN 542-56-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C61052A) of Isobutyl Nitrite (542-56-3) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C61052B) of Isobutyl Nitrite (542-56-3) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C61052A) of Isobutyl Nitrite (542-56-3) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C61052B) of Isobutyl Nitrite (542-56-3) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C61052B) of Isobutyl Nitrite (542-56-3) in F344/N Rats via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C61052B) of Isobutyl Nitrite (542-56-3) in B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C61052B) of Isobutyl Nitrite (542-56-3) in F344/N Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C61052B) of Isobutyl Nitrite (542-56-3) in B6C3F1 Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Isobutyl Nitrite (542-56-3) in Micronucleus Study A87798 in B6C3F1 Mice
Genetic Toxicity Evaluation of Isobutyl Nitrite in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 234350
Summary Data
Genetic Toxicity Evaluation of Isobutyl Nitrite in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 507924
Summary Data
Genetic Toxicity Evaluation of Isobutyl Nitrite in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 983397
Summary Data