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Ethynyl estradiol (57-63-6)


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Ethynyl estradiol (57-63-6).
Micronucleus - Mice
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  • Male: Negative
    Female: Negative
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Ethynyl estradiol (57-63-6).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Ethynyl estradiol (57-63-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-548 Toxicology and Carcinogenesis Study of Ethinyl Estradiol in Sprague-Dawley Rats (Feed Study)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Study Data


Toxicity and Carcinogenicity Studies


2-Week Evaluation of the Toxicity (C20326) of Ethinyl Estradiol (57-63-6) in F344 Rats Exposed via Subcutaneous Injection. NTP Special Study
26-Week Evaluation of the Toxicity (C97011E) of Transgenic Model (Ethinyl Estradiol) (57-63-6) in FVB/N Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C97011F) of Transgenic Model (Ethinyl Estradiol) (57-63-6) in FVB/N Mice Exposed via Gavage. NTP Special Study
2-Week Evaluation of the Toxicity (C97011E) of Transgenic Model (Ethinyl Estradiol) (57-63-6) in FVB/N Mice Exposed via Topical Application
2-Week Evaluation of the Toxicity (C97011F) of Transgenic Model (Ethinyl Estradiol) (57-63-6) in FVB/N Mice Exposed via Gavage
26-Week Evaluation of the Toxicity (C97011E) of Transgenic Model (Ethinyl Estradiol) (57-63-6) in Tg.AC (FVB/N) Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C97011F) of Transgenic Model (Ethinyl Estradiol) (57-63-6) in Tg.AC (FVB/N) Mice Exposed via Gavage. NTP Special Study
Evaluation of Multigeneraltional Toxicity and Carcinogenicity (MG96006) of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in CD Rats Exposed via Dosed Feed
Evaluation of Multigeneraltional Toxicity and Carcinogenicity (MG96006) of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in CD Rats Exposed via Dosed Feed
Special Evaluation of the Toxicity (MG96006) of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in CD Rats Exposed via Dosed Feed
Special Evaluation of the Toxicity (MG96006) of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in CD Rats Exposed via Dosed Feed
Special Evaluation of the Toxicity (MG96006) of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in CD Rats Exposed via Dosed Feed
Special Evaluation of the Toxicity (MG96006) of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in CD Rats Exposed via Dosed Feed
Special Evaluation of the Toxicity (MG96006) of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in CD Rats Exposed via Dosed Feed
Special Evaluation of the Toxicity (MG96006) of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in CD Rats Exposed via Dosed Feed
Special Evaluation of the Toxicity (MG96006) of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in CD Rats Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in Micronucleus Study A39469 in FVB/N Mice
Genetic Toxicity Evaluation of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in Micronucleus Study A51448 in FVB/N Mice
Genetic Toxicity Evaluation of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in Micronucleus Study A93135 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Endocrine Disruptor (Ethinyl Estradiol) (57-63-6) in Micronucleus Study A99151 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Endocrine Disruptor (Ethinyl Estradiol) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 018582
Summary Data