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Bromodichloromethane (75-27-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1020198


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Male, Rats
View
  • Clear Evidence, Male, Rats
View
  • Clear Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Male, Mice
View
  • No Evidence, Female, Mice
View
  • Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Bromodichloromethane (75-27-4).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Male: Equivocal
    Female: Equivocal
View
  • Female: Negative
View
  • Male: Negative
    Female: Negative
View
  • Male: Equivocal
    Female: Negative
View
  • Male: Equivocal
    Female: Negative
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Bromodichloromethane (75-27-4).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Bromodichloromethane (75-27-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Bromodichloromethane (75-27-4).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information


NTP. Bromodichloromethane (75-27-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-321 Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
TR-532 Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in Male F344/N Rats and Female B6C3F1 Mice (Drinking Water Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
GMM-05 Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137

Study Data


Toxicity and Carcinogenicity Studies


21-Day Evaluation of the Toxicity (C96018) of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in F344/N Rats Exposed via Dosed Water
21-Day Evaluation of the Toxicity (C96018) of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in B6C3F1 Mice Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Female B6C3F1 Mice Exposed via Gavage
2-Week Evaluation of the Toxicity (C97013F) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in FVB/N Mice Exposed via Topical Application
26-Week Evaluation of the Toxicity (C97013E) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53 +/- (C57BL/6) Mice Exposed via Dosed Water. NTP Special Study
26-Week Evaluation of the Toxicity (C97013G) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53 +/- (C57BL/6) Mice Exposed via Gavage. NTP Special Study
39-Week Evaluation of the Toxicity (C97013J) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53 +/- (C57BL/6) Mice Exposed via Dosed Water. NTP Special Study
39-Week Evaluation of the Toxicity (C97013K) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53 +/- (C57BL/6) Mice Exposed via Gavage. NTP Special Study
26-39 Week Evaluation of the Toxicity (C97013J) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53(C57BL/6) Mice Exposed via Dosed Water
26-39 Week Evaluation of the Toxicity (C97013K) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53(C57BL/6) Mice Exposed via Gavage
26-Week Evaluation of the Toxicity (C97013E) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53(C57BL/6) Mice Exposed via Dosed Water
26-Week Evaluation of the Toxicity (C97013G) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53(C57BL/6) Mice Exposed via Gavage
26-39 Week Evaluation of the Toxicity (C97013J) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Dosed Water
26-39 Week Evaluation of the Toxicity (C97013K) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Gavage
26-Week Evaluation of the Toxicity (C97013E) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Dosed Water
26-Week Evaluation of the Toxicity (C97013F) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Topical Application
26-Week Evaluation of the Toxicity (C97013F) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Topical Application
26-Week Evaluation of the Toxicity (C97013G) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Gavage
26-Week Evaluation of the Toxicity (C99001) of Transgenic Model (Bromodichloromethane) (75-27-4) in Tg.APC Mice Exposed via Gavage
26-Week Evaluation of the Toxicity (C99001B) of Transgenic Model (Bromodichloromethane) (75-27-4) in Tg.APC Mice Exposed via Dosed Water
26-Week Evaluation of the Toxicity (C97013E) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Dosed Water. NTP Special Study
26-Week Evaluation of the Toxicity (C97013F) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C97013G) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Gavage. NTP Special Study
39-Week Evaluation of the Toxicity (C97013F) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Topical Application. NTP Special Study
39-Week Evaluation of the Toxicity (C97013J) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Dosed Water. NTP Special Study
39-Week Evaluation of the Toxicity (C97013K) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Gavage. NTP Special Study
Evaluation of the Chronic Toxicity and Carcinogenicity of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C96018) of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in F344/N Rats Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity (C96018) of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in B6C3F1 Mice Exposed via Dosed Water
1-Year Evaluation of the Toxicity (C99038) of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in P53(C57BL/6) Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A08959 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A38548 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A39408 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A42280 in B6C3F1 Mice
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A55870 in P53 +/- (C57BL/6) Mice
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A78486 in B6C3F1 Mice
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A90924 in P53 +/- (C57BL/6) Mice
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 038604
Summary Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A68248
Summary Data

Other NTP Studies


ADME/TK Evaluation (S0527) of Bromodichloromethane (75-27-4) in F344 Rats Exposed via Gavage Administration
Toxicokinetic Evaluation (C96018) of Bromodichloromethane (75-27-4) in F344/N Rats and B6C3F1 Mice Exposed via Gavage or Intravenous Injection (Amended Study Report)