Bromodichloromethane (75-27-4)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1020198
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
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| Mammalian Cell Mutagenicity |
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| CA | SCE |
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Publications
TR-321
Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
TR-532
Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in Male F344/N Rats and Female B6C3F1 Mice (Drinking Water Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
GMM-05
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
Study Data
Toxicity and Carcinogenicity Studies
21-Day Evaluation of the Toxicity (C96018) of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in F344/N Rats Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
21-Day Evaluation of the Toxicity (C96018) of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in B6C3F1 Mice Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Female B6C3F1 Mice Exposed via Gavage
2-Week Evaluation of the Toxicity (C97013F) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in FVB/N Mice Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013E) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53 +/- (C57BL/6) Mice Exposed via Dosed Water. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
26-Week Evaluation of the Toxicity (C97013G) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53 +/- (C57BL/6) Mice Exposed via Gavage. NTP Special Study
39-Week Evaluation of the Toxicity (C97013J) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53 +/- (C57BL/6) Mice Exposed via Dosed Water. NTP Special Study
39-Week Evaluation of the Toxicity (C97013K) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53 +/- (C57BL/6) Mice Exposed via Gavage. NTP Special Study
26-39 Week Evaluation of the Toxicity (C97013J) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53(C57BL/6) Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-39 Week Evaluation of the Toxicity (C97013K) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53(C57BL/6) Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013E) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53(C57BL/6) Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013G) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in P53(C57BL/6) Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-39 Week Evaluation of the Toxicity (C97013J) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-39 Week Evaluation of the Toxicity (C97013K) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013E) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013F) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Topical Application
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013F) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Topical Application
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013G) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C99001) of Transgenic Model (Bromodichloromethane) (75-27-4) in Tg.APC Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C99001B) of Transgenic Model (Bromodichloromethane) (75-27-4) in Tg.APC Mice Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
26-Week Evaluation of the Toxicity (C97013E) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Dosed Water. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
26-Week Evaluation of the Toxicity (C97013F) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Topical Application. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
26-Week Evaluation of the Toxicity (C97013G) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Gavage. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
39-Week Evaluation of the Toxicity (C97013F) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Topical Application. NTP Special Study
39-Week Evaluation of the Toxicity (C97013J) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Dosed Water. NTP Special Study
39-Week Evaluation of the Toxicity (C97013K) of Water Disinfection Model (Bromodichloromethane) (75-27-4) in Tg.AC (FVB/N) Mice Exposed via Gavage. NTP Special Study
Evaluation of the Chronic Toxicity and Carcinogenicity of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C96018) of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in F344/N Rats Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C96018) of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in B6C3F1 Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female Individual Animal Pathology Data
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
1-Year Evaluation of the Toxicity (C99038) of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in P53(C57BL/6) Mice via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A08959 in Tg.AC (FVB/N) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A38548 in Tg.AC (FVB/N) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A39408 in Tg.AC (FVB/N) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A42280 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A55870 in P53 +/- (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A78486 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) (75-27-4) in Micronucleus Study A90924 in P53 +/- (C57BL/6) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 038604
Summary Data
- G06 - Ames Summary Data (135 KB)
Genetic Toxicity Evaluation of Water Disinfection Byproducts (Bromodichloromethane) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A68248
Other NTP Studies
ADME/TK Evaluation (S0527) of Bromodichloromethane (75-27-4) in F344 Rats Exposed via Gavage Administration
Toxicokinetic Evaluation (C96018) of Bromodichloromethane (75-27-4) in F344/N Rats and B6C3F1 Mice Exposed via Gavage or Intravenous Injection (Amended Study Report)
Toxicokinetic Evaluation (K05097) of Bromodichloromethane (DTXSID6026086) in Rat and Mouse
Data
- Annotated Group Parameters (26 kB)
- Original Data (95 kB)
- Summary Data - Mouse (200 kB)
- Summary Data - Rats (195 kB)