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1,2-Propylene oxide (75-56-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5021207


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Some Evidence, Male, Rats
View
  • Some Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Male, Mice
View
  • Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 1,2-Propylene oxide (75-56-9).
Rodent Cytogenetics
CA SCE
  • View
    • Positive (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,2-Propylene oxide (75-56-9).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,2-Propylene oxide (75-56-9).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,2-Propylene oxide (75-56-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1,2-Propylene oxide (75-56-9).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,2-Propylene oxide (75-56-9).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive
View
  • Positive

Citation Information


NTP. 1,2-Propylene oxide (75-56-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-267 Toxicology and Carcinogenesis Studies of Propylene Oxide (CASRN 75-56-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W., and Caspary, W. Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors. Environ. Molec. Mutagen. Vol. 17 (1991) 122-129
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Propylene Oxide (75-56-9) in Male F344 Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Propylene Oxide (75-56-9) in Female F344 Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Propylene Oxide (75-56-9) in Male B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Propylene Oxide (75-56-9) in Female B6C3F1 Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 1,2-Propylene Oxide (75-56-9) in Micronucleus Study 058372 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,2-Propylene Oxide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 373790
Summary Data
Genetic Toxicity Evaluation of 1,2-Propylene Oxide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 588849
Summary Data
Genetic Toxicity Evaluation of 1,2-Propylene Oxide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 723479
Summary Data