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tris(2-Ethylhexyl)phosphate (78-42-2)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0021414

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Equivocal Evidence, Male, Rats
View
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Male, Mice
View
  • Some Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to tris(2-Ethylhexyl)phosphate (78-42-2).
Rodent Cytogenetics
CA SCE
  • View
    • Positive (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to tris(2-Ethylhexyl)phosphate (78-42-2).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to tris(2-Ethylhexyl)phosphate (78-42-2).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to tris(2-Ethylhexyl)phosphate (78-42-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to tris(2-Ethylhexyl)phosphate (78-42-2).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to tris(2-Ethylhexyl)phosphate (78-42-2).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. tris(2-Ethylhexyl)phosphate (78-42-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-274 Toxicology and Carcinogenesis Studies of Tris(2-ethylhexyl)phosphate (CASRN 78-42-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of tris(2-Ethylhexyl)phosphate (78-42-2) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of tris(2-Ethylhexyl)phosphate (78-42-2) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of tris(2-Ethylhexyl)phosphate (78-42-2) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of tris(2-Ethylhexyl)phosphate (78-42-2) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of tris(2-Ethylhexyl)phosphate (78-42-2) in Micronucleus Study 143332 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of tris(2-Ethylhexyl)phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 323847
Summary Data

DTT Data Collections