Tetrabromobisphenol A (79-94-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1026081

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View Clear Evidence, Female, Rats Equivocal Evidence, Male, Rats

An overview of chronic evidence from Mice studies.
Mice
View No Evidence, Female, Mice Some Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Tetrabromobisphenol A (79-94-7).
Micronucleus - Mice
View Male: Negative Female: Negative

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Tetrabromobisphenol A (79-94-7).
Bacterial Mutagenicity
View Negative
View Negative

Citation Information

NTP. Tetrabromobisphenol A (79-94-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TR-587 Toxicology Studies of Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)

Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119

Ryan KR, Sirenko O, Parham F, Hsieh JH, Cromwell EF, Tice RR, Behl M. Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity. Neurotoxicology. 2016 Mar;53:271-281. doi: 10.1016/j.neuro.2016.02.003. Epub 2016 Feb 4. PMID: 26854185

Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh JH, Freedman JH, Boyd WA. Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans. Toxicol Sci. 2016 Dec;154(2):241-252. doi: 10.1093/toxsci/kfw162. Epub 2016 Aug 26. PMID: 27566445

Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol. 2017 May 1;322:60-74. doi: 10.1016/j.taap.2017.02.020. Epub 2017 Mar 1. PMID: 28259702

Nyffeler J, Dolde X, Krebs A, Pinto-Gil K, Pastor M, Behl M, Waldmann T, Leist M. Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library. Arch Toxicol. 2017 Nov;91(11):3613-3632. doi: 10.1007/s00204-017-1977-y. Epub 2017 May 5. PMID: 28477266

Sirenko O, Parham F, Dea S, Sodhi N, Biesmans S, Mora-Castilla S, Ryan K, Behl M, Chandy G, Crittenden C, Vargas-Hurlston S, Guicherit O, Gordon R, Zanella F, Carromeu C. Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures. Toxicol Sci. 2019 Jan 1;167(1):58-76. doi: 10.1093/toxsci/kfy218. PMID: 30169818

Alzualde A, Behl M, Sipes NS, Hsieh JH, Alday A, Tice RR, Paules RS, Muriana A, Quevedo C. Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance. Neurotoxicol Teratol. 2018 Nov-Dec;70:40-50. doi: 10.1016/j.ntt.2018.10.002. Epub 2018 Oct 9. PMID: 30312655

Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A. Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish. Toxicol Sci. 2019 Mar 1;168(1):225-240. doi: 10.1093/toxsci/kfy291. PMID: 30521027

Zhang S, Ireland D, Sipes NS, Behl M, Collins ES. Screening for neurotoxic potential of 15 flame retardants using freshwater planarians. Neurotoxicol Teratol. 2019 May-Jun;73:54-66. doi: 10.1016/j.ntt.2019.03.003. Epub 2019 Mar 31. PMID: 30943442

Rock KD, Gillera SEA, Devarasetty P, Horman B, Knudsen G, Birnbaum LS, Fenton SE, Patisaul HB. Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats. Neurotoxicology. 2019 Dec;75:136-147. doi: 10.1016/j.neuro.2019.09.003. Epub 2019 Sep 18. PMID: 31541695

Bowen C, Childers G, Perry C, Martin N, McPherson CA, Lauten T, Santos J, Harry GJ. Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells. Chemosphere. 2020 Sep;255:126919. doi: 10.1016/j.chemosphere.2020.126919. Epub 2020 Apr 30. PMID: 32402876

Brown PR, Gillera SEA, Fenton SE, Yao HH. Developmental Exposure to Tetrabromobisphenol A Has Minimal Impact on Male Rat Reproductive Health. Reprod Toxicol. 2020 Aug;95:59-65. doi: 10.1016/j.reprotox.2020.05.003. Epub 2020 May 13. PMID: 32416200

Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol. 2022 Oct;38(5):781-807. doi: 10.1007/s10565-021-09603-2. Epub 2021 May 10. PMID: 33969458

Emond C, DeVito MJ, Birnbaum LS. A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. Toxicol Appl Pharmacol. 2021 Oct 1;428:115678. doi: 10.1016/j.taap.2021.115678. Epub 2021 Aug 11. PMID: 34390738

Castro L, Liu J, Yu L, Burwell AD, Saddler TO, Santiago LA, Xue W, Foley JF, Staup M, Flagler ND, Shi M, Birnbaum LS, Darlene D. Differential Receptor Tyrosine Kinase Phosphorylation in the Uterus of Rats Following Developmental Exposure to Tetrabromobisphenol A. Toxicol Res Appl. 2021 Jan-Dec;5:10.1177/23978473211047164. doi: 10.1177/23978473211047164. Epub 2021 Nov 18. PMID: 35071781

Dunnick JK, Sanders JM, Kissling GE, Johnson CL, Boyle MH, Elmore SA. Environmental chemical exposure may contribute to uterine cancer development: studies with tetrabromobisphenol A. Toxicol Pathol. 2015 Jun;43(4):464-73. doi: 10.1177/0192623314557335. Epub 2014 Dec 4. PMID: 25476797

Jarema KA, Hunter DL, Shaffer RM, Behl M, Padilla S. Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):194-209. doi: 10.1016/j.ntt.2015.08.010. Epub 2015 Sep 5. PMID: 26348672

Harvey JB, Osborne TS, Hong HH, Bhusari S, Ton TV, Pandiri AR, Masinde T, Dunnick J, Peddada S, Elmore S, Hoenerhoff MJ. Uterine Carcinomas in Tetrabromobisphenol A-exposed Wistar Han Rats Harbor Increased Tp53 Mutations and Mimic High-grade Type I Endometrial Carcinomas in Women. Toxicol Pathol. 2015 Dec;43(8):1103-13. doi: 10.1177/0192623315599256. Epub 2015 Sep 8. PMID: 26353976

Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES 3rd, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):181-93. doi: 10.1016/j.ntt.2015.09.003. Epub 2015 Sep 18. PMID: 26386178

Tetrabromobisphenol-A Promotes Early Adipogenesis and Lipogenesis in 3T3-L1 Cells Chappell VA, Janesick A, Blumberg B, Fenton S
Toxicological Sciences (2018) DOI: https://doi.org/10.1093/toxsci/kfy209 PMID: 30496566
DOI: https://doi.org/10.22427/NTP-DATA-021-00003-0001-0000-7

Repeat 5-day in vivo genomic dose response studies Fred Parham, Michele R Balik-Meisner, William M Gwinn, Matthew D Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, Bruce Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R Shah, Deepak Mav, Dhiral P Phadke, Georgia Roberts, Michael J DeVito, Scott S Auerbach

DOI: https://doi.org/10.22427/NTP-DATA-002-00099-0001-000-1

BioProject ID: PRJNA926950

Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito

CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Interlaboratory Study Dose Range Finding (DRF) data DOI: https://doi.org/10.22427/NTP-DATA-002-00102-0001-000-6

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

5-Day Evaluation of the Toxicity (C20033B-02) of Tetrabromobisphenol A (79-94-7) on Sprague-Dawley Rats Exposed via Gavage

Study Tables

I01 - Animal Removal Summary (37 kB)
I03 - Growth Curve (368 kB)
I03C - Growth Curve (376 kB)
I04 - Mean Body Weight Summary (76 kB)
I04G - Mean Body Weight Gain (62 kB)
I05 - Clinical Observations Summary (42 kB)
PA06 - Organ Weights Summary (65 kB)

Individual Animal Data

Individual Animal Body Weight Data (10 kB)
Individual Animal Clinical Observations Data (10 kB)
Individual Animal Organ Weight Data (9 kB)
Individual Animal Removal Reasons Data (7 kB)

Data

3-Month Evaluation of the Toxicity (C20320) of Tetrabromobisphenol A (79-94-7) in F344/NTac Rats Exposed via Gavage

Study Tables

E03 - Growth Curves (768 kB)
E04 - Mean Body Weights and Survival Table (57 kB)
E05 - Clinical Observations Summary (56 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (113 kB)
P04 - Neoplasms by Individual Animal (1 mB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (149 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (108 kB)
P14 - Individual Animal Pathology Data (263 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (118 kB)
P40 - Survival Curves (816 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (35 kB)
Female Individual Animal Clinical Observations (4 kB)
Female Individual Animal Non Neoplastic Pathology Data (43 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (35 kB)
Male Individual Animal Clinical Observations (3 kB)
Male Individual Animal Neoplastic Pathology Data (2 kB)
Male Individual Animal Non Neoplastic Pathology Data (45 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

3-Month Evaluation of the Toxicity (C20320) of Tetrabromobisphenol A (79-94-7) in B6C3F1/N Mice Exposed via Gavage

Study Tables

E03 - Growth Curves (749 kB)
E04 - Mean Body Weights and Survival Table (184 kB)
E05 - Clinical Observations Summary (24 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (69 kB)
P04 - Neoplasms by Individual Animal (1 mB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (94 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (46 kB)
P14 - Individual Animal Pathology Data (1 mB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (90 kB)
P40 - Survival Curves (811 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (34 kB)
Female Individual Animal Non Neoplastic Pathology Data (5 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (34 kB)
Male Individual Animal Non Neoplastic Pathology Data (14 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Evaluation of the Prechronic Toxicity (C20320) of Tetrabromobisphenol A (79-94-7 ) in F344/N Tac, Rat Exposed Via GAVAGE

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20320) of Tetrabromobisphenol A (79-94-7) in Wistar Han Rats Exposed via Gavage

Study Tables

E03 - Growth Curves (70 kB)
E04 - Mean Body Weights and Survival Table (24 kB)
E05 - Clinical Observations Summary (22 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (54 kB)
P04 - Neoplasms by Individual Animal (624 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (49 kB)
P08 - Statistical Analysis of Primary Tumors (208 kB)
P08 – Statistical Analysis of Primary Tumors of the Extended Uterine Evaluation (114 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (751 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (349 kB)
P10 – Statistical Analysis of Non-neoplastic Lesions of the Extended Uterine Evaluation (119 kB)
P11 - Statistical Analysis of Survival Data (24 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (598 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (56 kB)
P40 - Survival Curves (66 kB)
TBBPA Uterine Pathology in the Rats (426 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (441 kB)
Female Individual Animal Clinical Observations (132 kB)
Female Individual Animal Neoplastic Pathology Data (110 kB)
Female Individual Animal Non Neoplastic Pathology Data (501 kB)
Female Individual Animal Organ Weight Data (63 kB)
Female Individual Animal Survival Data (37 kB)
Male Individual Animal Body Weight Data (406 kB)
Male Individual Animal Clinical Observations (105 kB)
Male Individual Animal Neoplastic Pathology Data (82 kB)
Male Individual Animal Non Neoplastic Pathology Data (550 kB)
Male Individual Animal Organ Weight Data (63 kB)
Male Individual Animal Survival Data (37 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20320) of Tetrabromobisphenol A (79-94-7) in B6C3F1 Mice Exposed via Gavage

Study Tables

E03 - Growth Curves (67 kB)
E04 - Mean Body Weights and Survival Table (24 kB)
E05 - Clinical Observations Summary (20 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (54 kB)
P04 - Neoplasms by Individual Animal (651 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (48 kB)
P08 - Statistical Analysis of Primary Tumors (193 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (762 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (324 kB)
P11 - Statistical Analysis of Survival Data (24 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (587 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (56 kB)
P40 - Survival Curves (67 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (448 kB)
Female Individual Animal Clinical Observations (29 kB)
Female Individual Animal Neoplastic Pathology Data (79 kB)
Female Individual Animal Non Neoplastic Pathology Data (366 kB)
Female Individual Animal Organ Weight Data (57 kB)
Female Individual Animal Survival Data (34 kB)
Male Individual Animal Body Weight Data (427 kB)
Male Individual Animal Clinical Observations (71 kB)
Male Individual Animal Neoplastic Pathology Data (144 kB)
Male Individual Animal Non Neoplastic Pathology Data (468 kB)
Male Individual Animal Organ Weight Data (57 kB)
Male Individual Animal Survival Data (34 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of Tetrabromobisphenol A (79-94-7) in Micronucleus Study A13260 in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (69 KB)
Individual Animal In Vivo Micronucleus Data (9 KB)

Data

Genetic Toxicity Evaluation of Tetrabromobisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 968573

Summary Data

G06 - Ames Summary Data (138 KB)

Data

Genetic Toxicity Evaluation of Tetrabromobisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G20033

Summary Data

G06 - Ames Summary Data (80 KB)

Other NTP Studies

ADME/TK Evaluation (S0897) of Tetrabromobisphenol A (79-94-7) in F344 Rats Exposed via Gavage or Intravenous Injection

Data

Screen for Developmental Toxicity in Zebrafish- Study 1

Results

Zebrafish 2,3,7,8-Tetrachlorodibenzo-p-dioxin CASRN 1746-01-6 (28 kB)
Zebrafish 1-Ethyl-3-methylimidazolium diethylphosphate CASRN 848641-69-0 (21 kB)
Zebrafish 1-Methyl-4-phenylpyridinium iodide CASRN 36913-39-0 (21 kB)
Zebrafish 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) CASRN 68631-49-2 (21 kB)
Zebrafish 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) CASRN 60348-60-9 (22 kB)
Zebrafish 2,2',4,4'-Tetrabromodiphenyl ether CASRN 5436-43-1 (28 kB)
Zebrafish 2-Ethylhexyl diphenyl phosphate (EHDP) CASRN 1241-94-7 (28 kB)
Zebrafish 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) CASRN 183658-27-7 (21 kB)
Zebrafish 2-Methoxyethanol CASRN 109-86-4 (22 kB)
Zebrafish 3,3'-Iminodipropionitrile CASRN 111-94-4 (22 kB)
Zebrafish 3,3’,5,5’-Tetrabromobisphenol A CASRN 79-94-7 (28 kB)
Zebrafish 4-H-Cyclopenta(d,e,f)phenanthrene CASRN 203-64-5 (28 kB)
Zebrafish 5-Fluorouracil CASRN 51-21-8 (21 kB)
Zebrafish 5-nitro-2-furaldehyde semicarbazone CASRN 59-87-0 (23 kB)
Zebrafish 6-Hydroxydopamine hydrochloride CASRN 28094-15-7 (21 kB)
Zebrafish 6-Propyl-2-thiouracil CASRN 51-52-5 (21 kB)
Zebrafish Acenaphthene CASRN 83-32-9 (28 kB)
Zebrafish Acenaphthylene CASRN 208-96-8 (28 kB)
Zebrafish Acetaminophen (4-hydroxyacetanilide) CASRN 103-90-2 (22 kB)
Zebrafish Acetic acid, manganese (2+) salt CASRN 638-38-0 (22 kB)
Zebrafish Acetylsalicylic acid CASRN 50-78-2 (21 kB)
Zebrafish Acrylamide CASRN 79-06-1 (22 kB)
Zebrafish Aldicarb CASRN 116-06-3 (28 kB)
Zebrafish Amoxicillin CASRN 26787-78-0 (21 kB)
Zebrafish Anthracene CASRN 120-12-7 (21 kB)
Zebrafish Auramine O CASRN 2465-27-2 (28 kB)
Zebrafish Benz(a)anthracene CASRN 56-55-3 (27 kB)
Zebrafish Benzo(a)pyrene CASRN 50-32-8 (27 kB)
Zebrafish Benzo(b)fluoranthene CASRN 205-99-2 (28 kB)
Zebrafish Benzo(e)pyrene CASRN 192-97-2 (28 kB)
Zebrafish Benzo(k)fluoranthene CASRN 207-08-9 (27 kB)
Zebrafish Benzog,h,i perylene CASRN 191-24-2 (21 kB)
Zebrafish Berberine chloride CASRN 633-65-8 (21 kB)
Zebrafish Bis(2-ethylhexyl) 3,4,5,6- tetrabromophthalate (TBPH) CASRN 26040-51-7 (21 kB)
Zebrafish Bis(tributyltin)oxide CASRN 56-35-9 (28 kB)
Zebrafish Bisphenol A CASRN 80-05-7 (27 kB)
Zebrafish Bisphenol AF CASRN 1478-61-1 (28 kB)
Zebrafish Bisphenol S CASRN 80-09-1 (21 kB)
Zebrafish Captan CASRN 133-06-2 (27 kB)
Zebrafish Carbamic acid, butyl-, 3-iodo-2-propynyl ester CASRN 55406-53-6 (28 kB)
Zebrafish Carbaryl CASRN 63-25-2 (27 kB)
Zebrafish Chlorpyrifos (Dursban) CASRN 2921-88-2 (27 kB)
Zebrafish Chrysene CASRN 218-01-9 (21 kB)
Zebrafish Colchicine CASRN 64-86-8 (27 kB)
Zebrafish D-Glucitol CASRN 50-70-4 (21 kB)
Zebrafish Deltamethrin CASRN 52918-63-5 (45 kB)
Zebrafish Di(2-ethylhexyl) phthalate CASRN 117-81-7 (22 kB)
Zebrafish Diazepam CASRN 439-14-5 (28 kB)
Zebrafish Dibenz a,c anthracene CASRN 215-58-7 (21 kB)
Zebrafish Dibenz(a,h)anthracene CASRN 53-70-3 (27 kB)
Zebrafish Dichlorodiphenyltrichloroethane (DDT) CASRN 50-29-3 (28 kB)
Zebrafish Dieldrin CASRN 60-57-1 (27 kB)
Zebrafish Diethylstilbestrol CASRN 56-53-1 (28 kB)
Zebrafish Estradiol CASRN 50-28-2 (28 kB)
Zebrafish Firemaster 550 CASRN 860302-33-6 (28 kB)
Zebrafish Fluorene CASRN 86-73-7 (28 kB)
Zebrafish Heptachlor CASRN 76-44-8 (28 kB)
Zebrafish Hexachlorophene CASRN 70-30-4 (28 kB)
Zebrafish Hydroxyurea CASRN 127-07-1 (21 kB)
Zebrafish Isodecyl diphenyl phosphate CASRN 29761-21-5 (27 kB)
Zebrafish L-Ascorbic acid CASRN 50-81-7 (21 kB)
Zebrafish Lead (II) acetate trihydrate CASRN 6080-56-4 (27 kB)
Zebrafish Lindane CASRN 58-89-9 (27 kB)
Zebrafish MPEP CASRN 95737-68-1 (29 kB)
Zebrafish Manganese, tricarbonyl (1,2,3,4,5-.eta.)-1-methyl-2,4-cyclopentadien-1-yl- CASRN 12108-13-3 (21 kB)
Zebrafish Methyl mercuric (II) chloride CASRN 115-09-3 (46 kB)
Zebrafish Naphthalene CASRN 91-20-3 (27 kB)
Zebrafish Parathion CASRN 56-38-2 (28 kB)
Zebrafish Permethrin CASRN 52645-53-1 (27 kB)
Zebrafish Phenanthrene CASRN 85-01-8 (28 kB)
Zebrafish Phenobarbital CASRN 50-06-6 (21 kB)
Zebrafish Phenobarbital sodium salt CASRN 57-30-7 (27 kB)
Zebrafish Phenol, isopropylated, phosphate (3 to1) CASRN 68937-41-7 (28 kB)
Zebrafish Pyrene CASRN 129-00-0 (27 kB)
Zebrafish Rotenone CASRN 83-79-4 (28 kB)
Zebrafish Saccharin Sodium Salt hydrate CASRN 82385-42-0 (33 kB)
Zebrafish Tebuconazole CASRN 107534-96-3 (28 kB)
Zebrafish Tetraethylthiuram disulfide CASRN 97-77-8 (28 kB)
Zebrafish Thalidomide CASRN 50-35-1 (27 kB)
Zebrafish Toluene CASRN 108-88-3 (21 kB)
Zebrafish Tricresyl phosphate CASRN 1330-78-5 (28 kB)
Zebrafish Triphenyl phosphate CASRN 115-86-6 (46 kB)
Zebrafish Tris(2-Chloroethyl) Phosphate CASRN 115-96-8 (21 kB)
Zebrafish Valinomycin CASRN 2001-95-8 (29 kB)
Zebrafish Valproic acid sodium salt CASRN 1069-66-5 (27 kB)
Zebrafish n-Hexane CASRN 110-54-3 (27 kB)
Zebrafish tert-Butylphenyl diphenyl phosphate CASRN 56803-37-3 (29 kB)
Zebrafish tris(Chloropropyl) phosphate, TCPP CASRN 13674-84-5 (27 kB)

Tetrabromobisphenol A (79-94-7)

Study Results

Chronic Bioassay Level of Evidence

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

5-Day Evaluation of the Toxicity (C20033B-02) of Tetrabromobisphenol A (79-94-7) on Sprague-Dawley Rats Exposed via Gavage

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C20320) of Tetrabromobisphenol A (79-94-7) in F344/NTac Rats Exposed via Gavage

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C20320) of Tetrabromobisphenol A (79-94-7) in B6C3F1/N Mice Exposed via Gavage

Study Tables

Individual Animal Data

Evaluation of the Prechronic Toxicity (C20320) of Tetrabromobisphenol A (79-94-7 ) in F344/N Tac, Rat Exposed Via GAVAGE

Evaluation of the Chronic Toxicity and Carcinogenicity (C20320) of Tetrabromobisphenol A (79-94-7) in Wistar Han Rats Exposed via Gavage

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20320) of Tetrabromobisphenol A (79-94-7) in B6C3F1 Mice Exposed via Gavage

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Tetrabromobisphenol A (79-94-7) in Micronucleus Study A13260 in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Tetrabromobisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 968573

Summary Data

Genetic Toxicity Evaluation of Tetrabromobisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G20033

Summary Data

Other NTP Studies

ADME/TK Evaluation (S0897) of Tetrabromobisphenol A (79-94-7) in F344 Rats Exposed via Gavage or Intravenous Injection

Screen for Developmental Toxicity in Zebrafish- Study 1

Results

NTP Data Collections