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Tetrabromobisphenol A (79-94-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1026081

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Female, Rats
  • Equivocal Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • Some Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Tetrabromobisphenol A (79-94-7).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Tetrabromobisphenol A (79-94-7).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information

NTP. Tetrabromobisphenol A (79-94-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-587 Toxicology Studies of Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Ryan KR, Sirenko O, Parham F, Hsieh JH, Cromwell EF, Tice RR, Behl M. Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity. Neurotoxicology. 2016 Mar;53:271-281. doi: 10.1016/j.neuro.2016.02.003. Epub 2016 Feb 4. PMID: 26854185
Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh JH, Freedman JH, Boyd WA. Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans. Toxicol Sci. 2016 Dec;154(2):241-252. doi: 10.1093/toxsci/kfw162. Epub 2016 Aug 26. PMID: 27566445
Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol. 2017 May 1;322:60-74. doi: 10.1016/j.taap.2017.02.020. Epub 2017 Mar 1. PMID: 28259702
Nyffeler J, Dolde X, Krebs A, Pinto-Gil K, Pastor M, Behl M, Waldmann T, Leist M. Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library. Arch Toxicol. 2017 Nov;91(11):3613-3632. doi: 10.1007/s00204-017-1977-y. Epub 2017 May 5. PMID: 28477266
Sirenko O, Parham F, Dea S, Sodhi N, Biesmans S, Mora-Castilla S, Ryan K, Behl M, Chandy G, Crittenden C, Vargas-Hurlston S, Guicherit O, Gordon R, Zanella F, Carromeu C. Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures. Toxicol Sci. 2019 Jan 1;167(1):58-76. doi: 10.1093/toxsci/kfy218. PMID: 30169818
Alzualde A, Behl M, Sipes NS, Hsieh JH, Alday A, Tice RR, Paules RS, Muriana A, Quevedo C. Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance. Neurotoxicol Teratol. 2018 Nov-Dec;70:40-50. doi: 10.1016/j.ntt.2018.10.002. Epub 2018 Oct 9. PMID: 30312655
Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A. Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish. Toxicol Sci. 2019 Mar 1;168(1):225-240. doi: 10.1093/toxsci/kfy291. PMID: 30521027
Zhang S, Ireland D, Sipes NS, Behl M, Collins ES. Screening for neurotoxic potential of 15 flame retardants using freshwater planarians. Neurotoxicol Teratol. 2019 May-Jun;73:54-66. doi: 10.1016/j.ntt.2019.03.003. Epub 2019 Mar 31. PMID: 30943442
Rock KD, Gillera SEA, Devarasetty P, Horman B, Knudsen G, Birnbaum LS, Fenton SE, Patisaul HB. Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats. Neurotoxicology. 2019 Dec;75:136-147. doi: 10.1016/j.neuro.2019.09.003. Epub 2019 Sep 18. PMID: 31541695
Bowen C, Childers G, Perry C, Martin N, McPherson CA, Lauten T, Santos J, Harry GJ. Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells. Chemosphere. 2020 Sep;255:126919. doi: 10.1016/j.chemosphere.2020.126919. Epub 2020 Apr 30. PMID: 32402876
Brown PR, Gillera SEA, Fenton SE, Yao HH. Developmental Exposure to Tetrabromobisphenol A Has Minimal Impact on Male Rat Reproductive Health. Reprod Toxicol. 2020 Aug;95:59-65. doi: 10.1016/j.reprotox.2020.05.003. Epub 2020 May 13. PMID: 32416200
Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol. 2022 Oct;38(5):781-807. doi: 10.1007/s10565-021-09603-2. Epub 2021 May 10. PMID: 33969458
Emond C, DeVito MJ, Birnbaum LS. A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. Toxicol Appl Pharmacol. 2021 Oct 1;428:115678. doi: 10.1016/j.taap.2021.115678. Epub 2021 Aug 11. PMID: 34390738
Castro L, Liu J, Yu L, Burwell AD, Saddler TO, Santiago LA, Xue W, Foley JF, Staup M, Flagler ND, Shi M, Birnbaum LS, Darlene D. Differential Receptor Tyrosine Kinase Phosphorylation in the Uterus of Rats Following Developmental Exposure to Tetrabromobisphenol A. Toxicol Res Appl. 2021 Jan-Dec;5:10.1177/23978473211047164. doi: 10.1177/23978473211047164. Epub 2021 Nov 18. PMID: 35071781
Dunnick JK, Sanders JM, Kissling GE, Johnson CL, Boyle MH, Elmore SA. Environmental chemical exposure may contribute to uterine cancer development: studies with tetrabromobisphenol A. Toxicol Pathol. 2015 Jun;43(4):464-73. doi: 10.1177/0192623314557335. Epub 2014 Dec 4. PMID: 25476797
Jarema KA, Hunter DL, Shaffer RM, Behl M, Padilla S. Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):194-209. doi: 10.1016/j.ntt.2015.08.010. Epub 2015 Sep 5. PMID: 26348672
Harvey JB, Osborne TS, Hong HH, Bhusari S, Ton TV, Pandiri AR, Masinde T, Dunnick J, Peddada S, Elmore S, Hoenerhoff MJ. Uterine Carcinomas in Tetrabromobisphenol A-exposed Wistar Han Rats Harbor Increased Tp53 Mutations and Mimic High-grade Type I Endometrial Carcinomas in Women. Toxicol Pathol. 2015 Dec;43(8):1103-13. doi: 10.1177/0192623315599256. Epub 2015 Sep 8. PMID: 26353976
Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES 3rd, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):181-93. doi: 10.1016/j.ntt.2015.09.003. Epub 2015 Sep 18. PMID: 26386178
Tetrabromobisphenol-A Promotes Early Adipogenesis and Lipogenesis in 3T3-L1 Cells Chappell VA, Janesick A, Blumberg B, Fenton S
Toxicological Sciences (2018) DOI: https://doi.org/10.1093/toxsci/kfy209 PMID: 30496566
DOI: https://doi.org/10.22427/NTP-DATA-021-00003-0001-0000-7
Repeat 5-day in vivo genomic dose response studies Fred Parham, Michele R Balik-Meisner, William M Gwinn, Matthew D Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, Bruce Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R Shah, Deepak Mav, Dhiral P Phadke, Georgia Roberts, Michael J DeVito, Scott S Auerbach

DOI: https://doi.org/10.22427/NTP-DATA-002-00099-0001-000-1

BioProject ID: PRJNA926950
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Interlaboratory Study Dose Range Finding (DRF) data DOI: https://doi.org/10.22427/NTP-DATA-002-00102-0001-000-6

Study Data

Protocol

Toxicity and Carcinogenicity Studies

5-Day Evaluation of the Toxicity (C20033B-02) of Tetrabromobisphenol A (79-94-7) on Sprague-Dawley Rats Exposed via Gavage
Study Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C20320) of Tetrabromobisphenol A (79-94-7) in F344/NTac Rats Exposed via Gavage
Study Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C20320) of Tetrabromobisphenol A (79-94-7) in B6C3F1/N Mice Exposed via Gavage
Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C20320) of Tetrabromobisphenol A (79-94-7) in Wistar Han Rats Exposed via Gavage
Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C20320) of Tetrabromobisphenol A (79-94-7) in B6C3F1 Mice Exposed via Gavage
Study Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Tetrabromobisphenol A (79-94-7) in Micronucleus Study A13260 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Tetrabromobisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 968573
Summary Data
Genetic Toxicity Evaluation of Tetrabromobisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G20033
Summary Data

Other NTP Studies

Screen for Developmental Toxicity in Zebrafish- Study 1
Results

DTT Data Collections