Black cohoshes
Publications
TR-603
Toxicity Studies of Black Cohosh Administered via Oral Gavage to Harlan Sprague-Dawley Rats and B6C3F1/N Mice
Mercado-Feliciano M, Cora MC, Witt KL, Granville CA, Hejtmancik MR, Fomby L, Knostman KA, Ryan MJ, Newbold R, Smith C, Foster PM, Vallant MK, Stout MD. Anethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents. Toxicol Appl Pharmacol. 2012 Sep 1;263(2):138-47. doi:10.1016/j.taap.2012.05.022. Epub 2012 Jun 9.
Mercado-Feliciano M, Cora MC, Witt KL, Granville CA, Hejtmancik MR, Fomby L, Knostman KA, Ryan MJ, Newbold R, Smith C, Foster PM, Vallant MK, Stout MD. Anethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents. Toxicol Appl Pharmacol. 2012 Sep 1;263(2):138-47. doi:10.1016/j.taap.2012.05.022. Epub 2012 Jun 9.
Study Data
Toxicity and Carcinogenicity Studies
Evaluation of the Chronic Toxicity and Carcinogenicity (C00058B) of Black Cohosh (84776-26-1 ) in HSD, Rat Exposed Via GAVAGE
Study Tables
- Adjusted Pup Body Weights (181 kB)
- E01 - Animal Removal Summary by Treatment Group (13 kB)
- E01 - Animal Removal Summary by Treatment Group - Female Pup (7 kB)
- E01 - Animal Removal Summary by Treatment Group - Male Pup (7 kB)
- E02 - Animals Removed from Experiment (156 kB)
- E02 - Animals Removed from Experiment - Female Pup (128 kB)
- E02 - Animals Removed from Experiment - Male Pup (130 kB)
- E03 - Growth Curves (486 kB)
- E03 - Growth Curves - Female Pup (28 kB)
- E03 - Growth Curves - Male Pup (28 kB)
- E03 - Growth Curves Litter Based (65 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E04 - Mean Body Weights and Survival Table - Female Pup (8 kB)
- E04 - Mean Body Weights and Survival Table - Male Pup (8 kB)
- E04 - Mean Body Weights and Survival Table Litter Based (18 kB)
- E05 - Clinical Observations Summary (22 kB)
- E12 - Animal History - Female Pup (1 mB)
- E12 - Animal History - Male Pup (1 mB)
- Gestational Body Weights (31 kB)
- Lactational Body Weights (163 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (55 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (70 kB)
- P04 - Neoplasms by Individual Animal (677 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (51 kB)
- P08 - Statistical Analysis of Primary Tumors Litter Based (227 kB)
- P08 - Statistical Analysis of Primary Tumors Step Section (120 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (957 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions Litter Based (564 kB)
- P11 - Statistical Analysis of Survival Data (29 kB)
- P11 - Statistical Analysis of Survival Data Litter Based (21 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (618 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (72 kB)
- P40 - Survival Curves (491 kB)
- P40 - Survival Curves - Female Pup (29 kB)
- P40 - Survival Curves - Male Pup (29 kB)
- PND 1 Litter Data (27 kB)
- PND 4 and 21 Litter Size and Survival (34 kB)
- R02 - Reproductive Performance Summary (38 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals (392 kB)
- Female Individual Animal Body Weight Data All Animals - Female Pup (224 kB)
- Female Individual Animal Clinical Observations (204 kB)
- Female Individual Animal Neoplastic Pathology Data (124 kB)
- Female Individual Animal Non Neoplastic Pathology Data (758 kB)
- Female Individual Animal Survival Data (34 kB)
- Female Individual Animal Survival Data - Female Pup (121 kB)
- Female Individual Animal Terminal Body Weight Data (57 kB)
- Individual Animal Clinical Observations Data (9 kB)
- Individual Animal DamID and PupID Data (17 kB)
- Individual Animal Reproductive Performance Data (11 kB)
- Individual Pup Census and Litter Weight by Sex Data (24 kB)
- Male Individual Animal Body Weight Data All Animals (391 kB)
- Male Individual Animal Body Weight Data All Animals - Male Pup (237 kB)
- Male Individual Animal Clinical Observations (257 kB)
- Male Individual Animal Neoplastic Pathology Data (103 kB)
- Male Individual Animal Non Neoplastic Pathology Data (906 kB)
- Male Individual Animal Survival Data (33 kB)
- Male Individual Animal Survival Data - Male Pup (128 kB)
- Male Individual Animal Terminal Body Weight Data (57 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C00058B) of Black Cohosh (84776-26-1 ) in B6C3F1/N, Mouse Exposed Via GAVAGE
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals (591 kB)
- Female Individual Animal Clinical Observations (48 kB)
- Female Individual Animal Neoplastic Pathology Data (165 kB)
- Female Individual Animal Non Neoplastic Pathology Data (525 kB)
- Female Individual Animal Survival Data (58 kB)
- Female Individual Animal Terminal Body Weight Data (98 kB)
- Individual Animal Bone Marrow Smear Data (12 kB)
- Individual Animal Hematology Data (17 kB)
Hematology and Bone Marrow and Spleen Organ Weight (3 and 12 Month)
- Abnormal Metarubicytes in Bone Marrow (27 kB)
- PA06 – Organ Weights Summary (45 kB)
- PA43 – Hematology Summary (275 kB)
- PA50 – Bone Marrow Smear Summary (165 kB)
Chronic Study Tables
- E01 - Animal Removal Summary by Treatment Group (9 kB)
- E02 - Animals Removed from Experiment (58 kB)
- E03 - Growth Curves (251 kB)
- E04 - Mean Body Weights and Survival Table (14 kB)
- E05 - Clinical Observations Summary (17 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (27 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (30 kB)
- P04 - Neoplasms by Individual Animal (418 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (22 kB)
- P08 - Statistical Analysis of Primary Tumors (54 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (470 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (135 kB)
- P11 - Statistical Analysis of Survival Data (14 kB)
- P14 - Individual Animal Pathology Data (572 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (330 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (31 kB)
- P40 - Survival Curves (237 kB)
3-Month Interim Study Tables
- E01 - Animal Removal Summary by Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (34 kB)
- E03 - Growth Curves (217 kB)
- E04 - Mean Body Weights and Survival Table (10 kB)
- E05 - Clinical Observations Summary (17 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (13 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (12 kB)
- P04 - Neoplasms by Individual Animal (59 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (14 kB)
- P06 - Organ Weight Summary (12 kB)
- P08 - Statistical Analysis of Primary Tumors (8 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (56 kB)
- P11 - Statistical Analysis of Survival Data (13 kB)
- P12 - Organ Weights by Individual Animal (103 kB)
- P13 - Organ Weights by Treatment Group (20 kB)
- P14 - Individual Animal Pathology Data (69 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (59 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (13 kB)
- P40 - Survival Curves (227 kB)
12-Month Study Tables
- E01 - Animal Removal Summary by Treatment Group (8 kB)
- E02 - Animals Removed from Experiment (25 kB)
- E03 - Growth Curves (218 kB)
- E04 - Mean Body Weights and Survival Table (11 kB)
- E05 - Clinical Observations Summary (17 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (14 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (12 kB)
- P04 - Neoplasms by Individual Animal (59 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (14 kB)
- P06 - Organ Weight Summary (12 kB)
- P08 - Statistical Analysis of Primary Tumors (9 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (58 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (14 kB)
- P11 - Statistical Analysis of Survival Data (13 kB)
- P12 - Organ Weights by Individual Animal (103 kB)
- P13 - Organ Weights by Treatment Group (20 kB)
- P14 - Individual Animal Pathology Data (71 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (59 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (13 kB)
- P40 - Survival Curves (225 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Actaea racemosa (Black Cohosh) XRM in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058V
Summary Data
- G06 - Ames Summary Data (68 KB)
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058 in Wistar Han Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058B in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058C in B6C3F1 Mice
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058E in B6C3F1 Mice
Genetic Toxicity Evaluation of Black Cohosh (BCE_3012781) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058Y
Summary Data
- G06 - Ames Summary Data (68 KB)
Genetic Toxicity Evaluation of Black Cohosh (BCE_BCO2.5-A2401090310) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058X
Summary Data
- G06 - Ames Summary Data (63 KB)
Genetic Toxicity Evaluation of Black Cohosh Extract (BCE2) (BCE_TP20141210-R) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058Z
Summary Data
- G06 - Ames Summary Data (63 KB)
Genetic Toxicity Evaluation of Black Cohosh in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A13815
Genetic Toxicity Evaluation of Black Cohosh in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058D
Genetic Toxicity Evaluation of Black Cohosh Extract (BCE3) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058W
Summary Data
- G06 - Ames Summary Data (85 KB)