TR-603: Black cohosh (84776-26-1)
Publications
TR-603
Toxicity Studies of Black Cohosh Administered via Oral Gavage to Harlan Sprague-Dawley Rats and B6C3F1/N Mice
Study Data
Toxicity and Carcinogenicity Studies
Evaluation of the Chronic Toxicity and Carcinogenicity (C00058B) of Black Cohosh (84776-26-1 ) in HSD, Rat Exposed Via GAVAGE
Study Tables
- Adjusted Pup Body Weights (181 kB)
- E01 - Animal Removal Summary by Treatment Group (13 kB)
- E01 - Animal Removal Summary by Treatment Group - Female Pup (7 kB)
- E01 - Animal Removal Summary by Treatment Group - Male Pup (7 kB)
- E02 - Animals Removed from Experiment (156 kB)
- E02 - Animals Removed from Experiment - Female Pup (128 kB)
- E02 - Animals Removed from Experiment - Male Pup (130 kB)
- E03 - Growth Curves (486 kB)
- E03 - Growth Curves - Female Pup (28 kB)
- E03 - Growth Curves - Male Pup (28 kB)
- E03 - Growth Curves Litter Based (65 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E04 - Mean Body Weights and Survival Table - Female Pup (8 kB)
- E04 - Mean Body Weights and Survival Table - Male Pup (8 kB)
- E04 - Mean Body Weights and Survival Table Litter Based (18 kB)
- E05 - Clinical Observations Summary (22 kB)
- E12 - Animal History - Female Pup (1 mB)
- E12 - Animal History - Male Pup (1 mB)
- Gestational Body Weights (31 kB)
- Lactational Body Weights (163 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (55 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (70 kB)
- P04 - Neoplasms by Individual Animal (677 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (51 kB)
- P08 - Statistical Analysis of Primary Tumors Litter Based (227 kB)
- P08 - Statistical Analysis of Primary Tumors Step Section (120 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (957 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions Litter Based (564 kB)
- P11 - Statistical Analysis of Survival Data (29 kB)
- P11 - Statistical Analysis of Survival Data Litter Based (21 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (618 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (72 kB)
- P40 - Survival Curves (491 kB)
- P40 - Survival Curves - Female Pup (29 kB)
- P40 - Survival Curves - Male Pup (29 kB)
- PND 1 Litter Data (27 kB)
- PND 4 and 21 Litter Size and Survival (34 kB)
- R02 - Reproductive Performance Summary (38 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals (392 kB)
- Female Individual Animal Body Weight Data All Animals - Female Pup (224 kB)
- Female Individual Animal Clinical Observations (204 kB)
- Female Individual Animal Neoplastic Pathology Data (124 kB)
- Female Individual Animal Non Neoplastic Pathology Data (758 kB)
- Female Individual Animal Survival Data (34 kB)
- Female Individual Animal Survival Data - Female Pup (121 kB)
- Female Individual Animal Terminal Body Weight Data (57 kB)
- Individual Animal Clinical Observations Data (9 kB)
- Individual Animal DamID and PupID Data (17 kB)
- Individual Animal Reproductive Performance Data (11 kB)
- Individual Pup Census and Litter Weight by Sex Data (24 kB)
- Male Individual Animal Body Weight Data All Animals (391 kB)
- Male Individual Animal Body Weight Data All Animals - Male Pup (237 kB)
- Male Individual Animal Clinical Observations (257 kB)
- Male Individual Animal Neoplastic Pathology Data (103 kB)
- Male Individual Animal Non Neoplastic Pathology Data (906 kB)
- Male Individual Animal Survival Data (33 kB)
- Male Individual Animal Survival Data - Male Pup (128 kB)
- Male Individual Animal Terminal Body Weight Data (57 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C00058B) of Black Cohosh (84776-26-1 ) in B6C3F1/N, Mouse Exposed Via GAVAGE
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals (591 kB)
- Female Individual Animal Clinical Observations (48 kB)
- Female Individual Animal Neoplastic Pathology Data (165 kB)
- Female Individual Animal Non Neoplastic Pathology Data (525 kB)
- Female Individual Animal Survival Data (58 kB)
- Female Individual Animal Terminal Body Weight Data (98 kB)
- Individual Animal Bone Marrow Smear Data (12 kB)
- Individual Animal Hematology Data (17 kB)
Hematology and Bone Marrow and Spleen Organ Weight (3 and 12 Month)
- Abnormal Metarubicytes in Bone Marrow (27 kB)
- PA06 – Organ Weights Summary (45 kB)
- PA43 – Hematology Summary (275 kB)
- PA50 – Bone Marrow Smear Summary (165 kB)
Chronic Study Tables
- E01 - Animal Removal Summary by Treatment Group (9 kB)
- E02 - Animals Removed from Experiment (58 kB)
- E03 - Growth Curves (251 kB)
- E04 - Mean Body Weights and Survival Table (14 kB)
- E05 - Clinical Observations Summary (17 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (27 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (30 kB)
- P04 - Neoplasms by Individual Animal (418 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (22 kB)
- P08 - Statistical Analysis of Primary Tumors (54 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (470 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (135 kB)
- P11 - Statistical Analysis of Survival Data (14 kB)
- P14 - Individual Animal Pathology Data (572 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (330 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (31 kB)
- P40 - Survival Curves (237 kB)
3-Month Interim Study Tables
- E01 - Animal Removal Summary by Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (34 kB)
- E03 - Growth Curves (217 kB)
- E04 - Mean Body Weights and Survival Table (10 kB)
- E05 - Clinical Observations Summary (17 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (13 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (12 kB)
- P04 - Neoplasms by Individual Animal (59 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (14 kB)
- P06 - Organ Weight Summary (12 kB)
- P08 - Statistical Analysis of Primary Tumors (8 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (56 kB)
- P11 - Statistical Analysis of Survival Data (13 kB)
- P12 - Organ Weights by Individual Animal (103 kB)
- P13 - Organ Weights by Treatment Group (20 kB)
- P14 - Individual Animal Pathology Data (69 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (59 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (13 kB)
- P40 - Survival Curves (227 kB)
12-Month Study Tables
- E01 - Animal Removal Summary by Treatment Group (8 kB)
- E02 - Animals Removed from Experiment (25 kB)
- E03 - Growth Curves (218 kB)
- E04 - Mean Body Weights and Survival Table (11 kB)
- E05 - Clinical Observations Summary (17 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (14 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (12 kB)
- P04 - Neoplasms by Individual Animal (59 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (14 kB)
- P06 - Organ Weight Summary (12 kB)
- P08 - Statistical Analysis of Primary Tumors (9 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (58 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (14 kB)
- P11 - Statistical Analysis of Survival Data (13 kB)
- P12 - Organ Weights by Individual Animal (103 kB)
- P13 - Organ Weights by Treatment Group (20 kB)
- P14 - Individual Animal Pathology Data (71 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (59 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (13 kB)
- P40 - Survival Curves (225 kB)