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Black cohosh (84776-26-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2030857

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Black cohosh (84776-26-1).
Micronucleus - Rats
View
  • Female: Positive
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Black cohosh (84776-26-1).
Micronucleus - Mice
View
  • Female: Positive
View
  • Female: Positive
View
  • Female: Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Black cohosh (84776-26-1).
Bacterial Mutagenicity
View
  • Equivocal
View
  • Negative
View
  • Negative
View
  • Negative

Citation Information

NTP. Black cohosh (84776-26-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-603 Toxicity Studies of Black Cohosh Administered via Oral Gavage to Harlan Sprague-Dawley Rats and B6C3F1/N Mice
A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice Michelle C. Cora, William Gwinn, Ralph Wilson, Debra King, Suramya Waidyanatha, Grace E. Kissling, Sukhdev S. Brar, Dorian Olivera, Chad Blystone, and Greg Travlos.
Toxicologic Pathology (2017) DOI: https://doi.org/10.1177/0192623317714343 PMID: 28618975
Black Cohosh Extracts and Powders Induce Micronuclei, A Biomarker of Genetic Damage, in Human Cells Stephanie L. Smith‐Roe, Carol D. Swartz, Kim G. Shepard, Steven M. Bryce, Stephen D. Dertinger, Suramya Waidyanatha, Grace E. Kissling, Scott S. Auerbach, Kristine L. Witt, and E. Zeiger.
Environmental and Molecular Mutagenesis (2018) DOI: https://doi.org/10.1002/em.22182 PMID: 29668046

DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0030-0000-7
Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract Derek T. Bernacki, Steven M. Bryce, Jeffrey C. Bemis, Stephen D. Dertinger, Kristine L. Witt, Stephanie L. Smith-Roe
Environmental and Molecular Mutagenesis, (in press): First Published: 30 September 2019 DOI: https://doi.org/10.1002/em.22334
An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents Minerva Mercado-Feliciano, Michelle C. Cora, Kristine L. Witt, Courtney A. Granville, Milton R. Hejtmancik, Laurene Fomby, Katherine A. Knostman, Michael J. Ryan, Retha Newbold, Cynthia Smith, Paul M. Foster, Molly K. Vallant, Matthew D. Stout
Toxicology and Applied Pharmacology (2012) DOI: https://doi.org/10.1016/j.taap.2012.05.022 PMID: 22687605

DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0031-0000-8

Study Data

Protocol

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Prechronic Toxicity (C20112) of Black Cohosh (84776-26-1) in Wistar Han Rats Exposed via Gavage
Study Tables
Micronucleus Data
Individual Animal Data
3-Month Evaluation of the Prechronic Toxicity (C00058) of Black Cohosh (84776-26-1) in B6C3F1 Mice Exposed via Gavage
Study Tables
Micronucleus Data
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C00058B) of Black Cohosh (84776-26-1 ) in HSD, Rat Exposed Via GAVAGE
Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C00058B) of Black Cohosh (84776-26-1 ) in B6C3F1/N, Mouse Exposed Via GAVAGE
Individual Animal Data
Hematology and Bone Marrow and Spleen Organ Weight (3 and 12 Month)
Chronic Study Tables
3-Month Interim Study Tables
12-Month Study Tables
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058 in Wistar Han Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058B in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058C in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058E in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Black Cohosh (BCE_3012781) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058Y
Summary Data
Genetic Toxicity Evaluation of Black Cohosh (BCE_BCO2.5-A2401090310) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058X
Summary Data
Genetic Toxicity Evaluation of Black Cohosh in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A13815
Summary Data
Genetic Toxicity Evaluation of Black Cohosh in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058D
Summary Data

Other Studies

NTP Data Collections