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Black cohosh (84776-26-1)


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Black cohosh (84776-26-1).
Micronucleus - Rats
View
  • Female: Positive
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Black cohosh (84776-26-1).
Micronucleus - Mice
View
  • Female: Positive
View
  • Female: Positive
View
  • Female: Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Black cohosh (84776-26-1).
Bacterial Mutagenicity
View
  • Equivocal
View
  • Negative
View
  • Negative
View
  • Negative

Citation Information


NTP. Black cohosh (84776-26-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract Derek T. Bernacki, Steven M. Bryce, Jeffrey C. Bemis, Stephen D. Dertinger, Kristine L. Witt, Stephanie L. Smith-Roe
Environmental and Molecular Mutagenesis, (in press): First Published: 30 September 2019 DOI: https://doi.org/10.1002/em.22334
A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice Michelle C. Cora, William Gwinn, Ralph Wilson, Debra King, Suramya Waidyanatha, Grace E. Kissling, Sukhdev S. Brar, Dorian Olivera, Chad Blystone, and Greg Travlos.
Toxicologic Pathology (2017) DOI: https://doi.org/10.1177/0192623317714343 PMID: 28618975
Black Cohosh Extracts and Powders Induce Micronuclei, A Biomarker of Genetic Damage, in Human Cells Stephanie L. Smith‐Roe, Carol D. Swartz, Kim G. Shepard, Steven M. Bryce, Stephen D. Dertinger, Suramya Waidyanatha, Grace E. Kissling, Scott S. Auerbach, Kristine L. Witt, and E. Zeiger.
Environmental and Molecular Mutagenesis (2018) DOI: https://doi.org/10.1002/em.22182 PMID: 29668046

DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0030-0000-7
An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents Minerva Mercado-Feliciano, Michelle C. Cora, Kristine L. Witt, Courtney A. Granville, Milton R. Hejtmancik, Laurene Fomby, Katherine A. Knostman, Michael J. Ryan, Retha Newbold, Cynthia Smith, Paul M. Foster, Molly K. Vallant, Matthew D. Stout
Toxicology and Applied Pharmacology (2012) DOI: https://doi.org/10.1016/j.taap.2012.05.022 PMID: 22687605

DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0031-0000-8

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Prechronic Toxicity (C20112) of Black Cohosh (84776-26-1) in Wistar Han Rats Exposed via Gavage
3-Month Evaluation of the Prechronic Toxicity (C00058) of Black Cohosh (84776-26-1) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058 in Wistar Han Rats
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058B in B6C3F1 Mice
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058C in B6C3F1 Mice
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058E in B6C3F1 Mice
Genetic Toxicity Evaluation of Black Cohosh (BCE_3012781) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058Y
Summary Data
Genetic Toxicity Evaluation of Black Cohosh (BCE_BCO2.5-A2401090310) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058X
Summary Data
Genetic Toxicity Evaluation of Black Cohosh in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A13815
Summary Data
Genetic Toxicity Evaluation of Black Cohosh in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058D
Summary Data