Black cohosh (84776-26-1)
Publications
Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract
Derek T. Bernacki, Steven M. Bryce, Jeffrey C. Bemis, Stephen D. Dertinger, Kristine L. Witt, Stephanie L. Smith-Roe
Environmental and Molecular Mutagenesis, (in press): First Published: 30 September 2019 DOI: https://doi.org/10.1002/em.22334
Environmental and Molecular Mutagenesis, (in press): First Published: 30 September 2019 DOI: https://doi.org/10.1002/em.22334
A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice
Michelle C. Cora, William Gwinn, Ralph Wilson, Debra King, Suramya Waidyanatha, Grace E. Kissling, Sukhdev S. Brar, Dorian Olivera, Chad Blystone, and Greg Travlos.
Toxicologic Pathology (2017) DOI: https://doi.org/10.1177/0192623317714343 PMID: 28618975
Toxicologic Pathology (2017) DOI: https://doi.org/10.1177/0192623317714343 PMID: 28618975
Black Cohosh Extracts and Powders Induce Micronuclei, A Biomarker of Genetic Damage, in Human Cells
Stephanie L. SmithâRoe, Carol D. Swartz, Kim G. Shepard, Steven M. Bryce, Stephen D. Dertinger, Suramya Waidyanatha, Grace E. Kissling, Scott S. Auerbach, Kristine L. Witt, and E. Zeiger.
Environmental and Molecular Mutagenesis (2018) DOI: https://doi.org/10.1002/em.22182 PMID: 29668046
DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0030-0000-7
Environmental and Molecular Mutagenesis (2018) DOI: https://doi.org/10.1002/em.22182 PMID: 29668046
DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0030-0000-7
An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents
Minerva Mercado-Feliciano, Michelle C. Cora, Kristine L. Witt,
Courtney A. Granville, Milton R. Hejtmancik, Laurene Fomby, Katherine A. Knostman, Michael J. Ryan, Retha Newbold, Cynthia Smith, Paul M. Foster, Molly K. Vallant, Matthew D. Stout
Toxicology and Applied Pharmacology (2012) DOI: https://doi.org/10.1016/j.taap.2012.05.022 PMID: 22687605
DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0031-0000-8
Toxicology and Applied Pharmacology (2012) DOI: https://doi.org/10.1016/j.taap.2012.05.022 PMID: 22687605
DOI: https://doi.org/10.22427/NTP-DATA-002-01731-0031-0000-8
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Prechronic Toxicity (C20112) of Black Cohosh (84776-26-1) in Wistar Han Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary by Treatment Group (18 kB)
- E02 - Animals Removed from Experiment (38 kB)
- E03 - Growth Curves (232 kB)
- E04 - Mean Body Weights and Survival Table (13 kB)
- E05 - Clinical Observations Summary (8 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (17 kB)
- P14 - Individual Animal Pathology Data (101 kB)
Micronucleus Data
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals (39 kB)
- Female Individual Animal Clinical Observations (2 kB)
- Female Individual Animal Non Neoplastic Pathology Data (55 kB)
- Female Individual Animal Survival Data (11 kB)
- Female Individual Animal Terminal Body Weight Data (19 kB)
- Individual Animal Clinical Chemistry Data (10 kB)
- Individual Animal DamID and PupID_Data (6 kB)
- Individual Animal Hematology Data (11 kB)
- Individual Animal Organ Weight Data (10 kB)
3-Month Evaluation of the Prechronic Toxicity (C00058) of Black Cohosh (84776-26-1) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary by Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (40 kB)
- E03 - Growth Curves (241 kB)
- E04 - Mean Body Weights and Survival Table (15 kB)
- E05 - Clinical Observations Summary (10 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (16 kB)
- PA06 - Organ_Weights_Summary (66 kB)
- PA43 - Hematology_Summary (145 kB)
Micronucleus Data
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals (62 kB)
- Female Individual Animal Clinical Observations (7 kB)
- Female Individual Animal Non Neoplastic Pathology Data (28 kB)
- Female Individual Animal Survival Data (16 kB)
- Female Individual Animal Terminal Body Weight Data (26 kB)
- Individual Animal Hematology Data (14 kB)
- Individual Animal Organ Weight Data (10 kB)
- Litter Census (182 kB)
- Organ Weights (68 kB)
- Pup Litter Records (55 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058 in Wistar Han Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058B in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058C in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Black Cohosh (84776-26-1) in Micronucleus Study G00058E in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Black Cohosh (BCE_3012781) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058Y
Summary Data
- G06 - Ames Summary Data (68 KB)
Genetic Toxicity Evaluation of Black Cohosh (BCE_BCO2.5-A2401090310) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058X
Summary Data
- G06 - Ames Summary Data (63 KB)
Genetic Toxicity Evaluation of Black Cohosh in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A13815
Genetic Toxicity Evaluation of Black Cohosh in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G00058D
Summary Data
- G06 - Ames Summary Data (74 KB)