Tetrahydrofuran (109-99-9)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1021328
Study Results
Chronic Bioassay Level of Evidence
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| Mice | |
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Genetic Toxicology
| Rodent Cytogenetics |
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| CA |
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| Micronucleus - Mice |
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| Mammalian Cell Cytogenetics | |
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| CA | SCE |
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| Drosophila Germ Cell Mutagenicity |
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| Bacterial Mutagenicity |
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Publications
TR-475
Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Toxicity (C60560B) of Tetrahydrofuran (109-99-9) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C60560B) of Tetrahydrofuran (109-99-9) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C60560C) of Tetrahydrofuran (109-99-9) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C60560C) of Tetrahydrofuran (109-99-9) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Tetrahydrofuran (109-99-9) in Micronucleus Study A34612 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Tetrahydrofuran in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 551903
Summary Data
- G06 - Ames Summary Data (128 KB)
Genetic Toxicity Evaluation of Tetrahydrofuran in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 620162
Summary Data
- G06 - Ames Summary Data (134 KB)