Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Tetrachloroethylene (127-18-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2021319

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Male, Rats
View
  • Inadequate Study, Male, Rats
View
  • Some Evidence, Female, Rats
View
  • Inadequate Study, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Male, Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice
View
  • Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Tetrachloroethylene (127-18-4).
Rodent Cytogenetics
CA
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Tetrachloroethylene (127-18-4).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Tetrachloroethylene (127-18-4).
Mammalian Cell Mutagenicity
View
  • Equivocal
View
  • Equivocal
View
  • Equivocal
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Tetrachloroethylene (127-18-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Tetrachloroethylene (127-18-4).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Tetrachloroethylene (127-18-4).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Tetrachloroethylene (127-18-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-013 Bioassay of Tetrachloroethylene for Possible Carcinogenicity (CASRN 127-18-4)
TR-311 Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) (CASRN 127-18-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrachloroethylene (127-18-4) in Male F344 Rats via Whole Body Respiratory Exposure
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrachloroethylene (127-18-4) in Female F344 Rats via Whole Body Respiratory Exposure
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrachloroethylene (127-18-4) in Male Osborne-Mendel Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrachloroethylene (127-18-4) in Female Osborne-Mendel Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrachloroethylene (127-18-4) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrachloroethylene (127-18-4) in Male B6C3F1 Mice via Whole Body Respiratory Exposure
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrachloroethylene (127-18-4) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrachloroethylene (127-18-4) in Female B6C3F1 Mice via Whole Body Respiratory Exposure
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Tetrachloroethylene (127-18-4) in Micronucleus Study 245795 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Tetrachloroethylene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 269792
Summary Data

DTT Data Collections