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L-Ascorbic acid (50-81-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020106


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to L-Ascorbic acid (50-81-7).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to L-Ascorbic acid (50-81-7).
Micronucleus - Mice
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  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to L-Ascorbic acid (50-81-7).
Mammalian Cell Mutagenicity
View
  • Equivocal
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to L-Ascorbic acid (50-81-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to L-Ascorbic acid (50-81-7).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to L-Ascorbic acid (50-81-7).
Bacterial Mutagenicity
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  • Weakly Positive
View
  • Negative

Citation Information


NTP. L-Ascorbic acid (50-81-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-247 Carcinogenesis Bioassay of L-Ascorbic Acid (Vitamin C) (CASRN 50-81-7) in F344/N Rats and B6C3F1 Mice (Feed Study)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of L-Ascorbic Acid (50-81-7) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of L-Ascorbic Acid (50-81-7) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of L-Ascorbic Acid (50-81-7) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of L-Ascorbic Acid (50-81-7) in Female B6C3F1 Mice Exposed via Dosed Feed

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Results