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1,3-Dichloro-1-propene (542-75-6)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1022057

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Male, Rats
View
  • Some Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Inadequate Study, Male, Mice
View
  • Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 1,3-Dichloro-1-propene (542-75-6).
Rodent Cytogenetics
CA SCE
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,3-Dichloro-1-propene (542-75-6).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,3-Dichloro-1-propene (542-75-6).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,3-Dichloro-1-propene (542-75-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1,3-Dichloro-1-propene (542-75-6).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,3-Dichloro-1-propene (542-75-6).
Bacterial Mutagenicity
View
  • Positive

Citation Information

NTP. 1,3-Dichloro-1-propene (542-75-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-269 Toxicology and Carcinogenesis Studies of Telone® (Technical-Grade 1,3-Dichloropropane [CASRN 542-75-6] Containing 1.0 Epichlorohydrin as a Stabilizer) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 1,3-Dichloropropene (Telone II) (542-75-6) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,3-Dichloropropene (Telone II) (542-75-6) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,3-Dichloropropene (Telone II) (542-75-6) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,3-Dichloropropene (Telone II) (542-75-6) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 1,3-Dichloropropene (Telone II) (542-75-6) in Micronucleus Study 441206 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,3-Dichloropropene (Telone II) (542-75-6) in Micronucleus Study A15433 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,3-Dichloropropene (Telone II) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 172972
Summary Data

NTP Data Collections