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Diethylstilbestrol (56-53-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3020465

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Diethylstilbestrol (56-53-1).
Micronucleus - Mice
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  • Female: Positive
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  • Male: Negative
    Female: Negative
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  • Female: Positive
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  • Male: Negative
    Female: Negative
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  • Female: Negative
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  • Male: Negative
    Female: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Diethylstilbestrol (56-53-1).
Mammalian Cell Mutagenicity
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  • Positive
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  • Positive
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  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Diethylstilbestrol (56-53-1).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Diethylstilbestrol (56-53-1).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Diethylstilbestrol (56-53-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
Final Report on the Developmental Toxicity of Diethylstilbestrol in Swiss (CD-1) Mice
Final Report on the Developmental Toxicity of Diethylstilbestrol in Swiss (CD-1) Mice
Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
Gene Expression Alterations in Immune System Pathways in the Thymus Following Exposure to Immunosuppressive Chemicals Rachel Frawley, Kimber White, Jr., Ronnetta Brown, Deborah Musgrove, Nigel Walker, Dori Germolec
Environmental Health Perspectives (2011) DOI: https://doi.org/10.1289/ehp.1002358 PMID: 21041162
DOI: https://doi.org/10.22427/NTP-DATA-002-00086-0001-0000-6
Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Interlaboratory Study Dose Range Finding (DRF) data DOI: https://doi.org/10.22427/NTP-DATA-002-00102-0001-000-6

Study Data

Protocol

Toxicity and Carcinogenicity Studies

26-Week Evaluation of the Toxicity (C97011G) of Transgenic Model (DES) (56-53-1) in FVB/N Mice Exposed via Topical Application. NTP Special Study
Pathology Tables
Individual Animal Data
26-Week Evaluation of the Toxicity (C97011H) of Transgenic Model (DES) (56-53-1) in FVB/N Mice Exposed via Gavage. NTP Special Study
Pathology Tables
Individual Animal Data
2-Week Evaluation of the Toxicity (C97011H) of Transgenic Model (DES) (56-53-1) in FVB/N Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
26-Week Evaluation of the Toxicity (C97011G) of Transgenic Model (DES) (56-53-1) in FVB/N Mice Exposed via Topical Application
Pathology Tables
Individual Animal Data
26-Week Evaluation of the Toxicity (C97011H) of Transgenic Model (DES) (56-53-1) in FVB/N Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
26-Week Evaluation of the Toxicity (C97011G) of Transgenic Model (DES) (56-53-1) in Tg.AC (FVB/N) Mice Exposed via Topical Application. NTP Special Study
Pathology Tables
Individual Animal Data
26-Week Evaluation of the Toxicity (C97011H) of Transgenic Model (DES) (56-53-1) in Tg.AC (FVB/N) Mice Exposed via Gavage. NTP Special Study
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Diethylstilbestrol (56-53-1) in Micronucleus Study A04328 in Tg.AC Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Diethylstilbestrol (56-53-1) in Micronucleus Study A06412 in FVB/N Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Diethylstilbestrol (56-53-1) in Micronucleus Study A27424 in BRCA1(+/+) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Diethylstilbestrol (56-53-1) in Micronucleus Study A30983 in FVB/N Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Diethylstilbestrol (56-53-1) in Micronucleus Study A66561 in Tg.AC Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Diethylstilbestrol (56-53-1) in Micronucleus Study A82167 in C3H Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Diethylstilbestrol (56-53-1) in Micronucleus Study A99812 in BRCA1(+/-) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Diethylstilbestrol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 209298
Summary Data

Other NTP Studies

Prenatal Developmental Toxicity Study (TER93137) of Diethylstilbestrol (56-53-1) in Swiss CD-1 Mice Exposed via Subcutaneous Injection
Individual and Summary Data
Screen for Developmental Toxicity in Zebrafish- Study 1
Results

NTP Data Collections