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3-Chloro-2-methylpropene (563-47-3)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Male, Rats
View
  • Clear Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Male, Mice
View
  • Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 3-Chloro-2-methylpropene (563-47-3).
Rodent Cytogenetics
CA SCE
  • View
    • Negative (Nonstandard Protocol)
  • View
    • Positive
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 3-Chloro-2-methylpropene (563-47-3).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 3-Chloro-2-methylpropene (563-47-3).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 3-Chloro-2-methylpropene (563-47-3).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 3-Chloro-2-methylpropene (563-47-3).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 3-Chloro-2-methylpropene (563-47-3).
Bacterial Mutagenicity
View
  • Weakly Positive
View
  • Negative
View
  • Negative

Citation Information


NTP. 3-Chloro-2-methylpropene (563-47-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-300 Toxicology and Carcinogenesis Studies of 3-Chloro-2-methylpropene (Technical grade containing 5% Dimethylvinyl chloride) (CASRN 563-47-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 3-Chloro-2-methylpropene (563-47-3) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 3-Chloro-2-methylpropene (563-47-3) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 3-Chloro-2-methylpropene (563-47-3) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 3-Chloro-2-methylpropene (563-47-3) in Female B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 3-Chloro-2-methylpropene (563-47-3) in Micronucleus Study 249137 in B6C3F1 Mice
Genetic Toxicity Evaluation of 3-Chloro-2-methylpropene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 154361
Summary Data
Genetic Toxicity Evaluation of 3-Chloro-2-methylpropene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 701637
Summary Data
Genetic Toxicity Evaluation of 3-Chloro-2-methylpropene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 933790
Summary Data